ArticleDiabetes2018
β-Cell DNA Damage Response Promotes Islet Inflammation in Type 1 Diabetes.
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Article in Diabetes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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43citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
What it found
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Who cites it
43 citing papers in PubMed, 58 citations in OpenAlex.
- Developmental Control of DNA Damage Responses in α- and β-Cells Shapes the Selective β-Cell Susceptibility in Diabetes.Diabetes · 2026Article
- Significance of p53-binding protein 1 as an in situ DNA damage marker for ulcerative colitis.Medical molecular morphology · 2026Article
- Elevated MANF expression in β cells protects mice from streptozotocin-induced diabetes by attenuating islet stress and immunogenicity.Molecular therapy : the journal of the American Society of Gene Therapy · 2026Article
- Toward Personalized Medicine in Type 1 Diabetes: Understanding How Patient Heterogeneity Influences Therapeutic Efficacy.Diabetes, obesity & metabolism · 2026Review
- Review
- Insulin production is sustained during DNA damage-mediated senescence in adult human beta cells.Diabetologia · 2026Article
- PLAGL1 overexpression exacerbates type 1 diabetes by inducing β-cell apoptosis via oxidative stress-dependent dual DNA damage and cGAS/STING pathway activation.Journal of diabetes investigation · 2026Article
- Developmental control of DNA damage responses in α- and β-cells shapes the selective beta-cell susceptibility in diabetes.bioRxiv : the preprint server for biology · 2025Article
- Autoreactive T Cells and Cytokine Stress Drive β-Cell Senescence Entry and Accumulation in Type 1 Diabetes.Diabetes · 2025Article
- DNA-PKcs-Driven YAP1 Phosphorylation and Nuclear Translocation: a Key Regulator of Ferroptosis in Hyperglycemia-Induced Cardiac Dysfunction in Type 1 Diabetes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- DNA repair protein RAD50 is involved in the streptozotocin-induced diabetes susceptibility of mice.Experimental animals · 2025Article
- Bcl-2 and Bcl-xL in Diabetes: Contributions to Endocrine Pancreas Viability and Function.Biomedicines · 2025Review
- Core circadian transcription factor Bmal1 mediates β cell response and recovery from pro-inflammatory injury.iScience · 2024Article
- Mitochondrial Reactive Oxygen Species Dysregulation in Heart Failure with Preserved Ejection Fraction: A Fraction of the Whole.Antioxidants (Basel, Switzerland) · 2024Review
- Safeguarding genomic integrity in beta-cells: implications for beta-cell differentiation, growth, and dysfunction.Biochemical Society transactions · 2024Review
- The downregulation of SCGN induced by lipotoxicity promotes NLRP3-mediated β-cell pyroptosis.Cell death discovery · 2024Article
- Senescence of human pancreatic beta cells enhances functional maturation through chromatin reorganization and promotes interferon responsiveness.Nucleic acids research · 2024Article
- Epigenetic Regulation of Pancreas Development and Function.Advances in anatomy, embryology, and cell biology · 2024Review
- ROS production by mitochondria: function or dysfunction?Oncogene · 2024Review
- Circulating Sphingolipids in Insulin Resistance, Diabetes and Associated Complications.International journal of molecular sciences · 2023Review
Corrections and comments
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Authors and funding
17 authors at 6 institutions in 4 countries.
Elad HorwitzDepartment of Developmental Biology and Cancer Research, The Hebrew University, Jerusalem, Israel.ORCID 0000-0003-0361-3374
Lars KrogvoldPaediatric Department, Oslo University Hospital HF, Faculty of Medicine, University of Oslo, Oslo, Norway.
Sophia ZhitomirskyDepartment of Developmental Biology and Cancer Research, The Hebrew University, Jerusalem, Israel.
Avital SwisaDepartment of Developmental Biology and Cancer Research, The Hebrew University, Jerusalem, Israel.
Maya FischmanDepartment of Developmental Biology and Cancer Research, The Hebrew University, Jerusalem, Israel.
Tsuria LaxDepartment of Developmental Biology and Cancer Research, The Hebrew University, Jerusalem, Israel.
Tehila DahanDepartment of Developmental Biology and Cancer Research, The Hebrew University, Jerusalem, Israel.
Noa HurvitzDepartment of Developmental Biology and Cancer Research, The Hebrew University, Jerusalem, Israel.
Noa Weinberg-CoremDepartment of Developmental Biology and Cancer Research, The Hebrew University, Jerusalem, Israel.
Agnes KlochendlerDepartment of Developmental Biology and Cancer Research, The Hebrew University, Jerusalem, Israel.
Alvin C PowersDivision of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, and Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN.ORCID 0000-0003-1941-5786
Marcela BrissovaDivision of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, and Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN.
Anne JörnsInstitute of Clinical Biochemistry, Hannover Medical School, Hannover, Germany.
Sigurd LenzenInstitute of Clinical Biochemistry, Hannover Medical School, Hannover, Germany.
Benjamin GlaserEndocrinology and Metabolism Service, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Knut Dahl-JørgensenPaediatric Department, Oslo University Hospital HF, Faculty of Medicine, University of Oslo, Oslo, Norway.
Yuval DorDepartment of Developmental Biology and Cancer Research, The Hebrew University, Jerusalem, Israel yuvald@ekmd.huji.ac.il knut.dahl-jorgensen@medisin.uio.no.ORCID 0000-0003-2456-2289
Hebrew University of Jerusalem · ILMedizinische Hochschule Hannover · DEOslo University Hospital · NOHadassah Medical Center · ILVanderbilt University Medical Center · USVA Tennessee Valley Healthcare System · US
Funding
Vanderbilt Diabetes Research CenterP30DK020593 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI OWEN P MCGUINNESS · 2012 to 2026
$29.3MSupplement to Integrated Program for Human Pancreas Procurement and AnalysisUC4DK112232 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ATKINSON, MARK A., POWERS, ALVIN C · 2016 to 2020
$8.4MMolecular Mechanisms of Human and Murine Beta Cell Proliferation and RegenerationU01DK089572 · NIDDK · VANDERBILT UNIVERSITY · PI GREINER, DALE LESLIE, HARLAN, DAVID MARSHALL · 2010 to 2014
$8.4MDiscovery of Pancreatic Signatures in Type 2 Diabetes MellitusR24DK106755 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CAI, LONG, CAPRIOLI, RICHARD M · 2015 to 2019
$6.2MHigh-resolution analysis of juvenile human pancreas maturationUC4DK108120 · NIDDK · VANDERBILT UNIVERSITY · PI CAI, LONG, GRADINARU, VIVIANA · 2015 to 2015
$4.4MMolecular Mechanisms of Physiologic Beta Cell Growth in Juvenile Human PancreasUC4DK104211 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KIM, SEUNG K, POWERS, ALVIN C · 2014 to 2015
$4.0MNon-Invasive Diagnosis of Human Beta Cell Damage and DeathUC4DK104216 · NIDDK · UNIVERSITY OF FLORIDA · PI SCHATZ, DESMOND ARTHUR · 2014 to 2014
$1.4MNIDDK NIH HHS P30 DK020593NIDDK NIH HHS R24 DK106755NIDDK NIH HHS U01 DK089572NIDDK NIH HHS UC4 DK104211NIDDK NIH HHS UC4 DK104216NIDDK NIH HHS UC4 DK108120NIDDK NIH HHS UC4 DK112232
Abstract
Type 1 diabetes (T1D) is an autoimmune disease where pancreatic β-cells are destroyed by islet-infiltrating T cells. Although a role for β-cell defects has been suspected, β-cell abnormalities are difficult to demonstrate. We show a β-cell DNA damage response (DDR), presented by activation of the 53BP1 protein and accumulation of p53, in biopsy and autopsy material from patients with recently diagnosed T1D as well as a rat model of human T1D. The β-cell DDR is more frequent in islets infiltrated by CD45
Indexed as
AdultAnimalsDiabetes Mellitus, ExperimentalDiabetes Mellitus, Type 1DNA DamageFemaleHumansInflammationInsulin-Secreting CellsIslets of LangerhansMaleMiceMiddle AgedYoung Adult
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.