ArticleInfection and immunity2018
Oral Immunization with Nontoxigenic Clostridium difficile Strains Expressing Chimeric Fragments of TcdA and TcdB Elicits Protective Immunity against C. difficile Infection in Both Mice and Hamsters.
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Article in Infection and immunity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 20 citations in OpenAlex.
- Immune Aspects of Clostridioides difficile Infection and Vaccine Development.Infectious disease clinics of North America · 2025Review
- Bioengineered Probiotics for Clostridioides difficile Infection: An Overview of the Challenges and Potential for This New Treatment Approach.Probiotics and antimicrobial proteins · 2025Review
- The state of play of rodent models for the study ofJournal of medical microbiology · 2024Review
- Review
- Multiplex genetic manipulations in Clostridium butyricum and Clostridium sporogenes to secrete recombinant antigen proteins for oral-spore vaccination.Microbial cell factories · 2024Article
- Immunization Strategies Against Clostridioides difficile.Advances in experimental medicine and biology · 2024Review
- Host Immunity and Immunization Strategies for Clostridioides difficile Infection.Clinical microbiology reviews · 2023Review
- Mucosal Vaccination Strategies againstVaccines · 2023Review
- Development of an Effective Nontoxigenic Clostridioides difficile-Based Oral Vaccine against C. difficile Infection.Microbiology spectrum · 2022Article
- Towards Development of a Non-ToxigenicPharmaceutics · 2022Article
- Genomic and Phenotypic Characterization of the Nontoxigenic Clostridioides difficile Strain CCUG37785 and Demonstration of Its Therapeutic Potential for the Prevention of C. difficile Infection.Microbiology spectrum · 2022Article
- Neutralizing epitopes onFrontiers in immunology · 2022Article
- Article
- Bioengineered Probiotics: Synthetic Biology Can Provide Live Cell Therapeutics for the Treatment of Foodborne Diseases.Frontiers in bioengineering and biotechnology · 2022Review
- Translational Aspects of the Immunology of Clostridioides difficile Infection: Implications for Pediatric Populations.Journal of the Pediatric Infectious Diseases Society · 2021Review
- FliW and CsrA Govern Flagellin (FliC) Synthesis and Play Pleiotropic Roles in Virulence and Physiology ofFrontiers in microbiology · 2021Article
- Vaccination againstInfection and immunity · 2019Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Yuanguo WangDepartment of Molecular Medicine, Morsani School of Medicine, University of South Florida, Tampa, Florida, USA.
Shaohui WangDepartment of Molecular Medicine, Morsani School of Medicine, University of South Florida, Tampa, Florida, USA.
Laurent BouillautDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts, USA.
Chunhui LiDepartment of Molecular Medicine, Morsani School of Medicine, University of South Florida, Tampa, Florida, USA.
Zhibian DuanDepartment of Molecular Medicine, Morsani School of Medicine, University of South Florida, Tampa, Florida, USA.
Keshan ZhangState Key Laboratory of Veterinary Etiological Biology, National Foot and Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.
Xianghong JuDepartment of Veterinary Medicine, Guangdong Ocean University, Zhanjiang, China.
Saul TziporiDepartment of Infectious Diseases and Global Health, Tufts University Cummings School of Veterinary Medicine, North Grafton, Massachusetts, USA.
Abraham L SonensheinDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts, USA.
Xingmin SunDepartment of Molecular Medicine, Morsani School of Medicine, University of South Florida, Tampa, Florida, USA sun5@health.usf.edu.
University of South Florida · USTufts University · USGuangdong Ocean University · CNLanzhou Veterinary Research Institute · CNShanxi Agricultural University · CN
Funding
ISOLATION OF EARLY SPORULATION GENESR01GM042219 · NIGMS · TUFTS UNIVERSITY BOSTON · PI SONENSHEIN, ABRAHAM LINCOLN · 1989 to 2015
$5.8MMultivalent vaccines against Clostridium difficile infectionR01AI132711 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI Xingmin Sun, Shifeng Wang · 2017 to 2026
$3.3MSignaling pathway of TNF-alpha production and Clostridium difficile infection (CDK01DK092352 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI SUN, XINGMIN · 2012 to 2016
$470kMultivalent Bacillus mucosal vaccines against Clostridium difficile infectionR21AI113470 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI SUN, XINGMIN · 2015 to 2016
$438kThe role of tumor progression locus 2 (TPL2) in the pathogenesis of Clostridium difficile infection (CDI)R03DK112004 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI SUN, XINGMIN · 2017 to 2018
$154kNIAID NIH HHS R01 AI132711NIAID NIH HHS R21 AI113470NIDDK NIH HHS K01 DK092352NIDDK NIH HHS R03 DK112004NIGMS NIH HHS R01 GM042219
Abstract
The symptoms of
Indexed as
Administration, OralAnimalsBacterial ProteinsBacterial ToxinsBacterial VaccinesClostridioides difficileClostridium InfectionsCricetinaeDisease Models, AnimalEnterotoxinsMiceRecombinant Fusion ProteinsSurvival AnalysisVaccines, AttenuatedVaccines, SyntheticBacterial ProteinsBacterial ToxinsBacterial VaccinesEnterotoxinsRecombinant Fusion ProteinstcdA protein, Clostridium difficiletoxB protein, Clostridium difficileVaccines, AttenuatedVaccines, SyntheticClostridium difficile infectionnontoxigenicoral immunizationvaccine
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.