Evidence map›Paper›PMID 30150232›Full record

ArticleJournal of bacteriology2018

Phage Morons Play an Important Role in Pseudomonas aeruginosa Phenotypes.

Yu-Fan Tsao, Véronique L Taylor, Smriti Kala, Joseph Bondy-Denomy, Alima N Khan, Diane Bona, Vincent Cattoir, Stephen Lory, Alan R Davidson, Karen L Maxwell

Abstract read
In one paragraph

Article in Journal of bacteriology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed
5.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 104 citations in OpenAlex.

  1. Revisiting the life cycle of temperate phages.Nature reviews. Microbiology · 2026
    Review
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  9. Antivirulence Activity and Therapeutic Potential of JumboJournal of microbiology and biotechnology · 2025
    Article
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  14. Article
  15. Genomic variation inMicrobiology spectrum · 2025
    Article
  16. Article
  17. Article
  18. Article
  19. Exploring Viral Interactions inLife (Basel, Switzerland) · 2025
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Yu-Fan TsaoDepartment of Molecular Genetics, University of Toronto, Toronto, Canada.
Véronique L TaylorDepartment of Biochemistry, University of Toronto, Toronto, Canada.
Smriti KalaDepartment of Biochemistry, University of Toronto, Toronto, Canada.
Joseph Bondy-DenomyDepartment of Molecular Genetics, University of Toronto, Toronto, Canada.
Alima N KhanDepartment of Biochemistry, University of Toronto, Toronto, Canada.
Diane BonaDepartment of Biochemistry, University of Toronto, Toronto, Canada.
Vincent CattoirDepartment of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0003-4026-9912
Stephen LoryDepartment of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, USA.
Alan R DavidsonDepartment of Molecular Genetics, University of Toronto, Toronto, Canada.
Karen L MaxwellDepartment of Biochemistry, University of Toronto, Toronto, Canada karen.maxwell@utoronto.ca.ORCID 0000-0002-0211-5480
University of Toronto · CAHarvard University · USUniversity of California, San Francisco · US

Funding

CIHR MOP-136845CIHR XNE-86943
6 · The paper itself

Abstract

The viruses that infect bacteria, known as phages, play a critical role in controlling bacterial populations in many diverse environments, including the human body. This control stems not only from phages killing bacteria but also from the formation of lysogens. In this state, the phage replication cycle is suppressed, and the phage genome is maintained in the bacterial cell in a form known as a prophage. Prophages often carry genes that benefit the host bacterial cell, since increasing the survival of the host cell by extension also increases the fitness of the prophage. These highly diverse and beneficial phage genes, which are not required for the life cycle of the phage itself, have been referred to as "morons," as their presence adds "more on" the phage genome in which they are found. While individual phage morons have been shown to contribute to bacterial virulence by a number of different mechanisms, there have been no systematic investigations of their activities. Using a library of phages that infect two different clinical isolates of

Indexed as

Genes, ViralPhenotypeAnimalsDrosophila melanogasterHost-Pathogen InteractionsLysogenyProphagesPseudomonas aeruginosaPseudomonas InfectionsPseudomonas PhagesSymbiosisVirulenceVirulence FactorsVirulence Factorsbacteriophage resistancebacteriophagesbiofilmsmotilityPseudomonas aeruginosa

Identifiers

PMID30150232
PMCPMC6199475
OpenAlexW2888912904

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.