Evidence map›Paper›PMID 30150002›Full record

ReviewTrends in parasitology2018

Genetic Crosses and Linkage Mapping in Schistosome Parasites.

Timothy J C Anderson, Philip T LoVerde, Winka Le Clec'h, Frédéric D Chevalier

Open access · greenAbstract readReview
In one paragraph

Review in Trends in parasitology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 51 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Schistosomiasis.Advances in experimental medicine and biology · 2024
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Schistosoma mansoni.Trends in parasitology · 2021
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Timothy J C AndersonTexas Biomedical Research Institute, San Antonio, Texas 78227, USA. Electronic address: tanderso@txbiomed.org.
Philip T LoVerdeUniversity of Texas Health, San Antonio, Texas 78229, USA.
Winka Le Clec'hTexas Biomedical Research Institute, San Antonio, Texas 78227, USA.
Frédéric D ChevalierTexas Biomedical Research Institute, San Antonio, Texas 78227, USA.
Texas Biomedical Research Institute · USThe University of Texas Health Science Center at San Antonio · US

Funding

Genetic Basis of Praziquantel ResistanceR01AI123434 · NIAID · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI ANDERSON, TIM J, LOVERDE, PHILIP T · 2016 to 2020
$3.5M
Structure-guided redesign of an antischistosomal drugR01AI115691 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI LOVERDE, PHILIP T · 2015 to 2019
$2.6M
Genetic analysis of cercarial release in schistosomesR01AI133749 · NIAID · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI ANDERSON, TIM J · 2017 to 2021
$2.5M
Genetic Analysis of Host Specificity in Schistosoma mansoniR01AI097576 · NIAID · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI ANDERSON, TIM J · 2012 to 2014
$1.7M
A Linkage Map for Schistosoma mansoniR21AI072704 · NIAID · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI ANDERSON, TIM J · 2007 to 2008
$466k
Efficient Linkage Mapping Methods for Schistosoma mansoniR21AI096277 · NIAID · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI ANDERSON, TIM J, LOVERDE, PHILIP T · 2012 to 2013
$453k
NIAID NIH HHS R01 AI097576NIAID NIH HHS R01 AI115691NIAID NIH HHS R01 AI123434NIAID NIH HHS R01 AI133749NIAID NIH HHS R21 AI072704NIAID NIH HHS R21 AI096277
6 · The paper itself

Abstract

Linkage mapping - utilizing experimental genetic crosses to examine cosegregation of phenotypic traits with genetic markers - is now 100 years old. Schistosome parasites are exquisitely well suited to linkage mapping approaches because genetic crosses can be conducted in the laboratory, thousands of progeny are produced, and elegant experimental work over the last 75 years has revealed heritable genetic variation in multiple biomedically important traits such as drug resistance, host specificity, and virulence. Application of this approach is timely because the improved genome assembly for Schistosoma mansoni and developing molecular toolkit for schistosomes increase our ability to link phenotype with genotype. We describe current progress and potential future directions of linkage mapping in schistosomes.

Indexed as

Chromosome MappingCrosses, GeneticGenetic VariationAnimalsGenetic MarkersGenotypeHost SpecificityPhenotypeSchistosomaSchistosoma mansoniSchistosomiasisVirulenceGenetic Markersfine mappingfunctional analysisheritabilitylinkagephenotypeSchistosoma

Identifiers

PMID30150002
PMCPMC6382074
OpenAlexW2888238047

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.