Evidence map›Paper›PMID 30149979›Full record

ReviewTrends in neurosciences2018

Inhibitory Plasticity of Mesocorticolimbic Circuits in Addiction and Mental Illness.

Alexey Ostroumov, John A Dani

Abstract readReview
In one paragraph

Review in Trends in neurosciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
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  7. Dopamine D1 receptor in medial prefrontal cortex mediates the effects of TAAR1 activation on chronic stress-induced cognitive and social deficits.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Article
  8. Restoring GABAFrontiers in molecular neuroscience · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Alexey OstroumovDepartment of Neuroscience, Mahoney Institute for Neurosciences, Perelman School for Medicine, Philadelphia, PA 19104, USA. Electronic address: alexeyo@pennmedicine.upenn.edu.
John A DaniDepartment of Neuroscience, Mahoney Institute for Neurosciences, Perelman School for Medicine, Philadelphia, PA 19104, USA. Electronic address: johndani@pennmedicine.upenn.edu.

Funding

STRUCTURE/FUNCTION OF EXCITATORY SYNAPTIC CHANNELSR01NS021229 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI DANI, JOHN A. · 1987 to 2021
$5.3M
CELLULAR MECHANISMS OF NICOTINE ADDICTIONR01DA009411 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI DANI, JOHN A. · 1997 to 2018
$5.0M
Alpha 5 nAChR is a Risk Factor within the Dopamine System for Nicotine AddictionR01DA036572 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI DANI, JOHN A. · 2014 to 2018
$2.3M
CHOLINERGIC INFLUENCES NEURONAL CIRCUIT EXCITABILITYR37NS021229 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI DANI, JOHN A. · 2000 to 2006
$2.1M
NIDA NIH HHS R01 DA009411NIDA NIH HHS R01 DA036572NINDS NIH HHS R01 NS021229NINDS NIH HHS R37 NS021229
6 · The paper itself

Abstract

Behavioral adaptations occur through remodeling of brain circuits, as arising, for instance, from experience-dependent synaptic plasticity. Drugs of abuse and aversive stimuli, such as stress, act on the mesocorticolimbic system, dysregulating adaptive mechanisms and leading to a variety of aberrant behaviors associated with neuropsychiatric disorders. Until recently, research in the field has commonly focused on experience-dependent synaptic plasticity at excitatory synapses. However, there is growing evidence that synaptic plasticity within inhibitory circuits is an important contributor to maladaptive behaviors. We speculate that restoring normal inhibitory synaptic transmission is a promising therapeutic target for correcting some of the circuit abnormalities underlying neuropsychiatric disorders.

Indexed as

AnimalsBehavior, AddictiveBrainHumansMental DisordersNeural InhibitionNeural PathwaysNeuronal PlasticitySynaptic TransmissionchloridedopamineDrugs of abuseGABAKCC2mesolimbicnucleus accumbensstressventral tegmental area

Identifiers

PMID30149979
PMCPMC6252277

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.