Evidence map›Paper›PMID 30149796›Full record

ArticleBMC neurology2018

Acute spontaneous intracerebral hemorrhage and traumatic brain injury are the most common causes of critical illness in the ICU and have high early mortality.

Ye-Ting Zhou, Dao-Ming Tong, Shao-Dan Wang, Song Ye, Ben-Wen Xu, Chen-Xi Yang

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05095857 (S-ketamine for Cortical Spreading Depolarisation in Patients With Severe Acute Brain Injury), which is not on this map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05095857 phase4recruitingnot on this mapstarted 2023, after this paper: background citation

S-ketamine for Cortical Spreading Depolarisation in Patients With Severe Acute Brain Injury

TypeinterventionalSponsorRigshospitalet, DenmarkRan2023 to 2028Enrolled400ConditionsSubarachnoid Hemorrhage, Aneurysmal, Intracerebral Hemorrhage, Traumatic Brain InjuryArmsS-ketamine, Isotonic saline (placebo)
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Intracerebral hemorrhage in COVID-19: A narrative review.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia · 2021
    Review
  12. Observational
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Ye-Ting ZhouDepartment of Surgery, Affiliated Shuyang Hospital, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Dao-Ming TongDepartment of Neurology, Affiliated Shuyang Hospital, Xuzhou Medical University, Xuzhou, Jiangsu, China. dmtong@xzhmu.edu.cn.
Shao-Dan WangDepartment of Intensive Care Medicine, Affiliated Shuyang Hospital, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Song YeDepartment of Surgery, Affiliated Shuyang Hospital, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Ben-Wen XuDepartment of Surgery, Affiliated Shuyang Hospital, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Chen-Xi YangDepartment of Surgery, Affiliated Shuyang Hospital, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Xuzhou Medical College · CN

Funding

Clinical Key Specialty Construction Project of Jiangsu Provence 20160017
6 · The paper itself

Abstract

backgroundCritical care covers multiple disciplines. However, the causes of critical illness in the ICU, particularly the most common causes, remain unclear. We aimed to investigate the incidence and the most common causes of critical illness and the corresponding early mortality rates in ICU patients.

methodsA retrospective cohort study was performed to examine critically ill patients (aged over 15 years) in the general ICU in Shuyang County in northern China (1/2014-12/2015). The incidences and causes of critical illnesses and their corresponding early mortality rates in the ICU were determined by an expert panel.

resultsDuring the 2-year study period, 1,211,138 person-years (PY) and 1645 critically ill patients (mean age, 61.8 years) were documented. The median Glasgow Coma Scale (GCS) score was 6 (range, 3-15). The mean acute physiology and chronic health evaluation II (APACHE II) score was 21.2 ± 6.8. The median length of the ICU stay was 4 days (range, 1-29 days). The most common causes of critical illness in the ICU were spontaneous intracerebral hemorrhage (SICH) (26%, 17.6/100,000 PY) and traumatic brain injury (TBI) (16.8%, 11.4/100,000 PY). During the first 7 days in the ICU, SICH was the most common cause of death (42.2%, 7.4/10,000 PY), followed by TBI (36.6%, 4.2/100,000 PY). Based on a logistic analysis, older patients had a significantly higher risk of death from TBI (risk ratio [RR], 1.7; 95% CI, 1.034-2.635), heart failure/cardiovascular crisis (RR, 0.2; 95% CI, 0.083-0.484), cerebral infarction (RR, 0.15; 95% CI, 0.050-0.486), or respiratory failure (RR, 0.35; 95% CI, 0.185-0.784) than younger patients. However, the risk of death from SICH in the two groups was similar.

conclusionsThe most common causes of critical illness in the ICU were SICH and TBI, and both critical illnesses showed a higher risk of death during the first 7 days in the ICU.

Indexed as

AdultAgedBrain Injuries, TraumaticCerebral HemorrhageChinaCritical IllnessFemaleGlasgow Coma ScaleHumansIncidenceIntensive Care UnitsMaleMiddle AgedRetrospective StudiesCausesCritical illnessEpidemiologyHead injuryIncidenceIntracerebral hemorrhageMortality

Identifiers

PMID30149796
PMCPMC6112133
OpenAlexW2888907791

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.