Evidence map›Paper›PMID 30149667›Full record

ArticleViruses2018

Genes for Membrane Transport Proteins: Not So Rare in Viruses.

Timo Greiner, Anna Moroni, James L Van Etten, Gerhard Thiel

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Modular architecture of KEMBO reports · 2025
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  11. Review
  12. Article
  13. A Functional KViruses · 2020
    Article
  14. Chloroviruses.Viruses · 2019
    Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 3 countries.

Timo GreinerUniversity Clinic for Psychiatry and Psychotherapy, Brandenburg Medical School, Immanuel Klinik Rüdersdorf, 15562 Rüdersdorf, Germany. t.greiner@immanuel.de.ORCID 0000-0002-0909-570X
Anna MoroniDepartment of Biosciences, University of Milan, 20133 Milan, Italy. anna.moroni@unimi.it.ORCID 0000-0002-1860-406X
James L Van EttenDepartment of Plant Pathology and Nebraska Center for Virology, University of Nebraska, Lincoln, NE 68583-0900, USA. jvanetten1@unl.edu.
Gerhard ThielMembrane Biophysics, Department of Biology, Technische Universität Darmstadt, 64287 Darmstadt, Germany. thiel@bio.tu-darmstadt.de.
Technische Universität Darmstadt · DEUniversity of Milan · ITUniversity of Nebraska–Lincoln · US

Funding

European Research Council 695078
6 · The paper itself

Abstract

Some viruses have genes encoding proteins with membrane transport functions. It is unknown if these types of proteins are rare or are common in viruses. In particular, the evolutionary origin of some of the viral genes is obscure, where other viral proteins have homologs in prokaryotic and eukaryotic organisms. We searched virus genomes in databases looking for transmembrane proteins with possible transport function. This effort led to the detection of 18 different types of putative membrane transport proteins indicating that they are not a rarity in viral genomes. The most abundant proteins are K⁺ channels. Their predicted structures vary between different viruses. With a few exceptions, the viral proteins differed significantly from homologs in their current hosts. In some cases the data provide evidence for a recent gene transfer between host and virus, but in other cases the evidence indicates a more complex evolutionary history.

Indexed as

AnimalsDatabases, Nucleic AcidEvolution, MolecularGene Transfer, HorizontalGenome, ViralHEK293 CellsHost-Pathogen InteractionsHumansMembrane Transport ProteinsPatch-Clamp TechniquesPhylogenyPotassium ChannelsSequence Homology, Amino AcidViral ProteinsVirusesMembrane Transport ProteinsPotassium ChannelsViral Proteinsalgae virusesATPaseion channelsMimiviridaePhycodnaviridaetransportervirus evolution

Identifiers

PMID30149667
PMCPMC6163359
OpenAlexW2888826317

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.