Evidence map›Paper›PMID 30149630›Full record

ArticleNanomaterials (Basel, Switzerland)2018

Evaluating Nanoshells and a Potent Biladiene Photosensitizer for Dual Photothermal and Photodynamic Therapy of Triple Negative Breast Cancer Cells.

Rachel S Riley, Rachel K O'Sullivan, Andrea M Potocny, Joel Rosenthal, Emily S Day

Abstract read
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Review
  2. Article
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  5. Article
  6. Review
  7. Mapping the influence of ligand electronics on the spectroscopic andDalton transactions (Cambridge, England : 2003) · 2023
    Article
  8. Article
  9. Review
  10. Review
  11. Review
  12. Photodynamic Therapy Induced Cell Death Mechanisms in Breast Cancer.International journal of molecular sciences · 2021
    Review
  13. Review
  14. Article
  15. Review
  16. Spectroscopic andInorganic chemistry · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Rachel S RileyDepartment of Biomedical Engineering, University of Delaware, Newark, DE 19716, USA. rsriley@seas.upenn.edu.
Rachel K O'SullivanDepartment of Biomedical Engineering, University of Delaware, Newark, DE 19716, USA. rkos@udel.edu.
Andrea M PotocnyDepartment of Chemistry & Biochemistry, University of Delaware, Newark, DE 19716, USA. apotocny@udel.edu.
Joel RosenthalDepartment of Chemistry & Biochemistry, University of Delaware, Newark, DE 19716, USA. joelr@udel.edu.ORCID 0000-0002-6814-6503
Emily S DayDepartment of Biomedical Engineering, University of Delaware, Newark, DE 19716, USA. emilyday@udel.edu.ORCID 0000-0002-8707-826X

Funding

Predictive Modeling & Optimal Control Framework for Model-Based Epidemic Response in DelawareP20GM103446 · NIGMS · UNIVERSITY OF DELAWARE · PI MELINDA K DUNCAN · 2012 to 2026
$67.2M
This renovation project will create over 1455 sq. ft. of state- of-the-art reseaP20GM104316 · NIGMS · UNIVERSITY OF DELAWARE · PI SCHMITZ, KARL ROBERT · 2014 to 2024
$26.8M
UDE COBRE: STRAINED MOLECULES FOR SYNTHESIS OF UNNATURAL AMINO ACIDSP20RR017716 · NCRR · UNIVERSITY OF DELAWARE · PI BEEBE, THOMAS PAUL · 2002 to 2011
$16.9M
NCRR NIH HHS P20 RR017716NIGMS NIH HHS P20 GM103446NIGMS NIH HHS P20 GM104316
6 · The paper itself

Abstract

Light-activated therapies are ideal for treating cancer because they are non-invasive and highly specific to the area of light application. Photothermal therapy (PTT) and photodynamic therapy (PDT) are two types of light-activated therapies that show great promise for treating solid tumors. In PTT, nanoparticles embedded within tumors emit heat in response to laser light that induces cancer cell death. In PDT, photosensitizers introduced to the diseased tissue transfer the absorbed light energy to nearby ground state molecular oxygen to produce singlet oxygen, which is a potent reactive oxygen species (ROS) that is toxic to cancer cells. Although PTT and PDT have been extensively evaluated as independent therapeutic strategies, they each face limitations that hinder their overall success. To overcome these limitations, we evaluated a dual PTT/PDT strategy for treatment of triple negative breast cancer (TNBC) cells mediated by a powerful combination of silica core/gold shell nanoshells (NSs) and palladium 10,10-dimethyl-5,15-bis(pentafluorophenyl)biladiene-based (Pd[DMBil1]-PEG

Indexed as

apoptosisbiladienecancernanoparticlepalladiumphotodynamic therapyphotoresponsivephotosensitizerphotothermal therapysynergy

Identifiers

PMID30149630
PMCPMC6164691

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.