Evidence map›Paper›PMID 30149605›Full record

ArticleNutrients2018

Association of Anabolic Effect of Calcitriol with Osteoclast-Derived Wnt 10b Secretion.

Chien-Lin Lu, Jia-Fwu Shyu, Chia-Chao Wu, Chi-Feng Hung, Min-Tser Liao, Wen-Chih Liu, Cai-Mei Zheng, Yi-Chou Hou, Yuh-Feng Lin, Kuo-Cheng Lu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
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  5. Article
  6. The role of WNT10B in physiology and disease: A 10-year update.Frontiers in cell and developmental biology · 2023
    Review
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  9. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Chien-Lin LuGraduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan. janlin0123@gmail.com.ORCID 0000-0002-9452-5179
Jia-Fwu ShyuGraduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan. shyujeff@mail.ndmctsgh.edu.tw.
Chia-Chao WuDivision of Nephrology, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan. wucc@ndmctsgh.edu.tw.ORCID 0000-0002-8772-011X
Chi-Feng HungSchool of Medicine, Fu-Jen Catholic University, New Taipei City 242, Taiwan. skin@mail.fju.edu.tw.
Min-Tser LiaoDepartment of Pediatrics, Taoyuan Armed Forces General Hospital, Taoyuan 325, Taiwan. liaoped804h@yahoo.com.tw.
Wen-Chih LiuGraduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan. wayneliu55@gmail.com.
Cai-Mei ZhengGraduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan. 11044@s.tmu.edu.tw.ORCID 0000-0003-0370-3951
Yi-Chou HouDivision of Nephrology, Department of Medicine, Cardinal-Tien Hospital, School of Medicine, Fu Jen Catholic University, New Taipei City 23155, Taiwan. athletics910@gmail.com.
Yuh-Feng LinGraduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan. linyf@shh.org.tw.
Kuo-Cheng LuGraduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan. kuochenglu@gmail.com.
Fu Jen Catholic University · TWTaipei Medical University-Shuang Ho Hospital · TWTri-Service General Hospital · TWTaipei Medical University · TWTungs' Taichung MetroHarbor Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Canonical Wnt (Wingless/Integrated) signaling is crucial in bone development and the Wnt ligand can promote osteoblast differentiation from mesenchymal progenitor cells. Calcitriol, an active vitamin D3, is used clinically for treatment of secondary hyperparathyroidism (SHPT) in chronic kidney disease (CKD) patients. The bone effects of calcitriol in SHPT remains uncertain. We hypothesized that calcitriol improves bone mass by suppressing osteoclast activity, and simultaneously promoting Wnt ligand secretion. We designed a cross-sectional study in maintenance hemodialysis patients to explore the effects of calcitriol on different bone turnover markers and specifically emphasized the Wnt 10b levels. Then, we explored the source of Wnt 10b secretion by using osteoclasts and osteoblasts treated with calcitriol in cell culture studies. Finally, we explored the effects of calcitriol on bone microarchitectures in CKD mice, using the 5/6 nephrectomy CKD animal model with analysis using micro-computed tomography. Calcitriol promoted the growth of both trabecular and cortical bones in the CKD mice. Wnt 10b and Procollagen 1

Indexed as

Renal DialysisAdultAgedAged, 80 and overAnabolic AgentsAnimalsBiomarkersBone RemodelingCalcitriolCells, CulturedCross-Sectional StudiesDisease Models, AnimalFemaleHumansHyperparathyroidism, SecondaryMaleAnabolic AgentsBiomarkersCalcitriolProto-Oncogene ProteinsWNT10B protein, humanWnt10b protein, mouseWnt10b protein, ratWnt Proteinsbone turnover markerscalcitriolhemodialysisWnt 10b

Identifiers

PMID30149605
PMCPMC6164019
OpenAlexW2888643316

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.