Evidence map›Paper›PMID 30149566›Full record

ArticleInternational journal of environmental research and public health2018

Prenatal Exposure to Perfluoroalkyl Substances and Birth Outcomes; An Updated Analysis from the Danish National Birth Cohort.

Qi Meng, Kosuke Inoue, Beate Ritz, Jørn Olsen, Zeyan Liew

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of environmental research and public health, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 7 pooled it
9.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 7 syntheses or guidelines pooled it, 133 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Qi MengDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA. quinn7meng@gmail.com.ORCID 0000-0003-4459-8668
Kosuke InoueDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA. koinoue@ucla.edu.
Beate RitzDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA. britz@ucla.edu.
Jørn OlsenDepartment of Clinical Epidemiology, Aarhus University Hospital, N 8200 Aarhus, Denmark. jo@ph.au.dk.
Zeyan LiewDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA. zeyanliew@ucla.edu.ORCID 0000-0002-9424-7869
University of California, Los Angeles · USAarhus University Hospital · DK

Funding

Neurodevelopmental Effects of Perfluorinated ChemicalsR00ES026729 · NIEHS · YALE UNIVERSITY · PI LIEW, ZEYAN · 2018 to 2020
$742k
Neurodevelopmental effects of Perfluorinated ChemicalsK99ES026729 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LIEW, ZEYAN · 2017 to 2018
$317k
NIEHS NIH HHS K99 ES026729NIEHS NIH HHS R00 ES026729
6 · The paper itself

Abstract

Perfluoroalkyl substances (PFASs) are widespread industrial pollutants that are extremely persistent in the environment. A previous study in the Danish National Birth Cohort (DNBC) found prenatal perfluorooctanoate (PFOA) exposure was associated with decreased birth weight, but had insufficient statistical power to evaluate adverse birth outcomes. Here, we conducted additional analyses in three samples originating from the DNBC for 3535 mothers and infant pairs to evaluate associations between prenatal PFASs exposures and low birth weight and preterm birth. Maternal plasma concentrations were measured for six types of PFASs in early pregnancy. Several PFASs were associated with a reduction in birth weight and gestational age. We estimated a nearly 2-fold increase in risks of preterm birth for the higher quartiles of PFOA and perflourooctanesulfonate (PFOS) exposure. In spline models, risk of preterm birth was increased for perfluorononanoic acid (PFNA), perfluoroheptane sulfonate (PFHpS) and perfluorodecanoic acid (PFDA) in higher exposure ranges. We also observed some elevated risks for low birth weight but these estimates were less precise. Our findings strengthen the evidence that in-utero PFASs exposures affect fetal growth. Future studies are needed to evaluate whether these associations persist with the decline of PFOA and PFOS in populations and should also investigate newer types of fluorinated compounds introduced more recently.

Indexed as

Prenatal Exposure Delayed EffectsDenmarkEnvironmental PollutantsFemaleFluorocarbonsHumansInfant, Low Birth WeightInfant, NewbornPregnancyPremature BirthEnvironmental PollutantsFluorocarbonsbirth outcomesDanish National Birth Cohortendocrine disruptersfetal growthperfluoroalkyl substancespregnancy

Identifiers

PMID30149566
PMCPMC6164159
OpenAlexW2796876645

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.