Evidence map›Paper›PMID 30149545›Full record

ReviewInternational journal of molecular sciences2018

Natural Products for the Treatment of Autoimmune Arthritis: Their Mechanisms of Action, Targeted Delivery, and Interplay with the Host Microbiome.

Steven Dudics, David Langan, Rakeshchandra R Meka, Shivaprasad H Venkatesha, Brian M Berman, Chun-Tao Che, Kamal D Moudgil

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05788705 (Evaluation of the Efficacy of Natural JAK_ STAT Pathways Inhibitors in Treatment of Patients With Rheumatoid Arthritis as a Complementary Medicine), which is not on this map. Cited by 66 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05788705 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Evaluation of the Efficacy of Natural JAK_ STAT Pathways Inhibitors in Treatment of Patients With Rheumatoid Arthritis as a Complementary Medicine

TypeinterventionalSponsorAdel A.GomaaRan2023 to 2025Enrolled75ConditionsRheumatoid ArthritisArms"apigenin" and "glycyrrhizin", "glycyrrhizin" and "boswellic acid", "placebo"
3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  19. Antiarthritic and Antinociceptive Properties of Ylang-Ylang (Current issues in molecular biology · 2024
    Article
  20. Review

6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Steven DudicsBaltimore Veterans Affairs Medical Center, Baltimore, MD 21201, USA. sdudics1@gmail.com.
David LanganBaltimore Veterans Affairs Medical Center, Baltimore, MD 21201, USA. david.langan@umaryland.edu.ORCID 0000-0002-4525-9767
Rakeshchandra R MekaBaltimore Veterans Affairs Medical Center, Baltimore, MD 21201, USA. Rmeka@som.umaryland.edu.
Shivaprasad H VenkateshaBaltimore Veterans Affairs Medical Center, Baltimore, MD 21201, USA. hvshivaprasad@gmail.com.
Brian M BermanFamily and Community Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA. bberman@som.umaryland.edu.
Chun-Tao CheMedicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA. chect@uic.edu.
Kamal D MoudgilBaltimore Veterans Affairs Medical Center, Baltimore, MD 21201, USA. kmoudgil@som.umaryland.edu.

Funding

Cochrane Complementary Medicine Field: Resource for ResearchR24AT001293 · NCCIH · UNIVERSITY OF MARYLAND BALTIMORE · PI BERMAN, BRIAN M, WIELAND, LISA SUSAN · 2003 to 2022
$9.4M
Scientific Analysis CoreP01AT002605 · NCCIH · UNIVERSITY OF MARYLAND BALTIMORE · PI BERMAN, BRIAN M · 2005 to 2009
$6.4M
Immune Modulation of Autoimmunity by Herbal ProductsR01AT004321 · NCCIH · UNIVERSITY OF MARYLAND BALTIMORE · PI MOUDGIL, KAMAL D · 2009 to 2012
$1.5M
Micro-RNAs as biomarkers and targets of herbal CAM in autoimmune arthritis.F31AT009421 · NCCIH · UNIVERSITY OF MARYLAND BALTIMORE · PI DUDICS, STEVEN · 2017 to 2018
$89k
Anti-arthritic activity and therapeutic use of novel joint-homing peptidesI01BX002424 · VA · BALTIMORE VA MEDICAL CENTER · PI MOUDGIL, KAMAL D · 2015 to 2018
–
BLRD VA I01 BX002424NCCIH NIH HHS F31 AT009421NCCIH NIH HHS P01 AT002605NCCIH NIH HHS R01 AT004321NCCIH NIH HHS R24 AT001293
6 · The paper itself

Abstract

Rheumatoid arthritis (RA) is a chronic, debilitating illness characterized by painful swelling of the joints, inflammation of the synovial lining of the joints, and damage to cartilage and bone. Several anti-inflammatory and disease-modifying drugs are available for RA therapy. However, the prolonged use of these drugs is associated with severe side effects. Furthermore, these drugs are effective only in a proportion of RA patients. Hence, there is a need to search for new therapeutic agents that are effective yet safe. Interestingly, a variety of herbs and other natural products offer a vast resource for such anti-arthritic agents. We discuss here the basic features of RA pathogenesis; the commonly used animal models of RA; the mainstream drugs used for RA; the use of well-characterized natural products possessing anti-arthritic activity; the application of nanoparticles for efficient delivery of such products; and the interplay between dietary products and the host microbiome for maintenance of health and disease induction. We believe that with several advances in the past decade in the characterization and functional studies of natural products, the stage is set for widespread clinical testing and/or use of these products for the treatment of RA and other diseases.

Indexed as

AnimalsAnti-Inflammatory AgentsArthritisArthritis, RheumatoidAutoimmune DiseasesBiological ProductsBiomarkersDisease Models, AnimalDrug CarriersDrug Delivery SystemsDrug Evaluation, PreclinicalHumansInflammation MediatorsMicrobiotaMolecular Targeted TherapyNanoparticlesAnti-Inflammatory AgentsBiological ProductsBiomarkersDrug CarriersInflammation MediatorsPlant Preparationsadjuvant-induced arthritisarthritiscelastrolcurcumindietary supplementsEGCGgreen teainflammationliposomesmicrobiomenanoparticlesnatural productsresveratrolrheumatoid arthritistargeted deliverytraditional medicineTripterygium wilfordiitriptolide

Identifiers

PMID30149545
PMCPMC6164747

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.