ArticleMaterials (Basel, Switzerland)2018
Production and Physicochemical Characterization of Cu-Doped Silicate Bioceramic Scaffolds.
Article in Materials (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Carnosine Biofunctionalized Hydroxyapatite Induces Copper-Driven Osteogenesis and Angiogenesis, Strengthening Its Bone Regenerative Capacities.ACS biomaterials science & engineering · 2025Article
- Addressing the challenges of infectious bone defects: a review of recent advances in bifunctional biomaterials.Journal of nanobiotechnology · 2025Review
- Recycling of Lead-Acid Battery Electrodes Using SbMaterials (Basel, Switzerland) · 2025Article
- Antimicrobial properties of bimetallic-containing mesoporous bioglass againstJournal of dental sciences · 2025Article
- Advances in Bioceramics for Bone Regeneration: A Narrative Review.Biomimetics (Basel, Switzerland) · 2024Review
- Copper metabolism in osteoarthritis and its relation to oxidative stress and ferroptosis in chondrocytes.Frontiers in molecular biosciences · 2024Review
- Carnosine, Zinc and Copper: A Menage a Trois in Bone and Cartilage Protection.International journal of molecular sciences · 2023Review
- Enhancing Bone Grafting Outcomes: A Comprehensive Review of Antibacterial Artificial Composite Bone Scaffolds.Medical science monitor : international medical journal of experimental and clinical research · 2023Review
- Bioceramic-based scaffolds with antibacterial function for bone tissue engineering: A review.Bioactive materials · 2022Review
- Mesoporous Bioactive Glasses Cytocompatibility Assessment: A Review of In Vitro Studies.Biomimetics (Basel, Switzerland) · 2021Review
- Development and evaluation of copper-containing mesoporous bioactive glasses for bone defects therapy.Microporous and mesoporous materials : the official journal of the International Zeolite Association · 2020Article
- Nanotechnology for angiogenesis: opportunities and challenges.Chemical Society reviews · 2020Review
- Regulation of the Ocular Cell/Tissue Response by Implantable Biomaterials and Drug Delivery Systems.Bioengineering (Basel, Switzerland) · 2020Review
- Photochemistry with Cyanines in the Near Infrared: A Step to Chemistry 4.0 Technologies.Chemistry (Weinheim an der Bergstrasse, Germany) · 2019Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Development of ion-releasing implantable biomaterials is a valuable approach for advanced medical therapies. In the effort of tackling this challenge, we explored the feasibility of porous bioceramic scaffolds releasing copper ions, which are potentially able to elicit angiogenetic and antibacterial effects. First, small amounts of CuO were incorporated in the base silicate glass during melting and the obtained powders were further processed to fabricate glass⁻ceramic scaffolds by sponge replica method followed by sinter crystallization. As the release of copper ions from these foams in simulated body fluid (SBF) was very limited, a second processing strategy was developed. Silicate glass⁻ceramic scaffolds were coated with a layer of Cu-doped mesoporous glass, which exhibited favorable textural properties (ultrahigh specific surface area >200 m²/g, mesopore size about 5 nm) for modulating the release of copper. All the produced scaffolds, containing biocompatible crystals of wollastonite (CaSiO₃), revealed high stability in a biological environment. Furthermore, the materials had adequate compressive strength (>10 MPa) for allowing safe manipulation during surgery. Overall, the results achieved in the present work suggest that these Cu-doped glass-derived scaffolds show promise for biomedical application and motivate further investigation of their suitability from a biological viewpoint.
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