ArticleMaterials (Basel, Switzerland)2018
Calcium Chloride Modified Alginate Microparticles Formulated by the Spray Drying Process: A Strategy to Prolong the Release of Freely Soluble Drugs.
Article in Materials (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 68 citations in OpenAlex.
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- Sodium Alginate-Natural Microencapsulation Material of Polymeric Microparticles.International journal of molecular sciences · 2022Review
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- Antibacterial and Biodegradable Polysaccharide-Based Films for Food Packaging Applications: Comparative Study.Materials (Basel, Switzerland) · 2022Article
- Evaluation and Optimization of Prolonged Release Mucoadhesive Tablets of Dexamethasone for Wound Healing: In Vitro-In Vivo Profiling in Healthy Volunteers.Pharmaceutics · 2022Article
- The Effect of Drug Heterogeneous Distributions within Core-Sheath Nanostructures on Its Sustained Release Profiles.Biomolecules · 2021Article
- Sustained In Vitro and In Vivo Delivery of Metformin from Plant Pollen-Derived Composite Microcapsules.Pharmaceutics · 2021Article
- Electrically Polarized Graphene-Blended Spacers for Organic Fouling Reduction in Forward Osmosis.Membranes · 2021Article
- Catechins within the Biopolymer Matrix-Design Concepts and Bioactivity Prospects.Antioxidants (Basel, Switzerland) · 2020Review
- Fucoidan Characterization: Determination of Purity and Physicochemical and Chemical Properties.Marine drugs · 2020Review
- Recent Trends in Three-Dimensional Bioinks Based on Alginate for Biomedical Applications.Materials (Basel, Switzerland) · 2020Review
- Effects of Starch Incorporation on the Physicochemical Properties and Release Kinetics of Alginate-Based 3D Hydrogel Patches for Topical Delivery.Pharmaceutics · 2020Article
- Freeze-Drying Technique for Microencapsulation ofMolecules (Basel, Switzerland) · 2020Article
- Composite Central Face Design-An Approach to Achieve Efficient Alginate Microcarriers.Polymers · 2019Article
- Polymeric Materials: Surfaces, Interfaces and Bioapplications.Materials (Basel, Switzerland) · 2019Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alginate (ALG) cross-linking by CaCl₂ is a promising strategy to obtain modified-release drug delivery systems with mucoadhesive properties. However, current technologies to produce CaCl₂ cross-linked alginate microparticles possess major disadvantages, such as a poor encapsulation efficiency of water-soluble drugs and a difficulty in controlling the process. Hence, this study presents a novel method that streamlines microparticle production by spray drying; a rapid, continuous, reproducible, and scalable technique enabling obtainment of a product with low moisture content, high drug loading, and a high production yield. To model a freely water-soluble drug, metformin hydrochloride (MF) was selected. It was observed that MF was successfully encapsulated in alginate microparticles cross-linked by CaCl₂ using a one-step drying process. Modification of ALG provided drug release prolongation-particles obtained from 2% ALG cross-linked by 0.1% CaCl₂ with a prolonged MF rate of dissolution of up to 12 h. Cross-linking of the ALG microparticles structure by CaCl₂ decreased the swelling ratio and improved the mucoadhesive properties which were evaluated using porcine stomach mucosa.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.