Evidence map›Paper›PMID 30149498›Full record

ReviewAntioxidants (Basel, Switzerland)2018

Role of Presenilin in Mitochondrial Oxidative Stress and Neurodegeneration in

Shaarika Sarasija, Kenneth R Norman

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Antioxidants (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 33 citations in OpenAlex.

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  15. Methods to Analyse Time-to-Event Data: The Kaplan-Meier Survival Curve.Oxidative medicine and cellular longevity · 2021
    Review
  16. Review
  17. The Role of CaCells · 2020
    Review
  18. Review
  19. Novel Approaches for the Treatment of Alzheimer's and Parkinson's Disease.International journal of molecular sciences · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Shaarika SarasijaDepartment of Regenerative and Cancer Cell Biology, Albany Medical College, Albany, NY 12208, USA. sarasis@amc.edu.ORCID 0000-0002-3610-2178
Kenneth R NormanDepartment of Regenerative and Cancer Cell Biology, Albany Medical College, Albany, NY 12208, USA. normank@amc.edu.
Albany Medical Center Hospital · US

Funding

Investigation of Calcium Signaling in Caenorhabditis elegansR01GM088213 · NIGMS · ALBANY MEDICAL COLLEGE · PI NORMAN, KENNETH R · 2010 to 2019
$2.8M
NIGMS NIH HHS R01 GM088213
6 · The paper itself

Abstract

Neurodegenerative diseases like Alzheimer's disease (AD) are poised to become a global health crisis, and therefore understanding the mechanisms underlying the pathogenesis is critical for the development of therapeutic strategies. Mutations in genes encoding presenilin (PSEN) occur in most familial Alzheimer's disease but the role of PSEN in AD is not fully understood. In this review, the potential modes of pathogenesis of AD are discussed, focusing on calcium homeostasis and mitochondrial function. Moreover, research using

Indexed as

alzheimer’s diseasecalciumC. elegansmitochondrianeurodegenerationpresenilinROS

Identifiers

PMID30149498
PMCPMC6162450
OpenAlexW2883296340

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.