ArticleJournal of exercise nutrition & biochemistry2018
Role of dihydrotestosterone in whole-body energy utilization during acute running exercise in mice.
Article in Journal of exercise nutrition & biochemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 6 citations in OpenAlex.
- Effects of post-exercise intake of exogenous lactate on energy substrate utilization at rest.Physical activity and nutrition · 2024Article
- The Effects of Exogenous Lactate Administration on the IGF1/Akt/mTOR Pathway in Rat Skeletal Muscle.International journal of environmental research and public health · 2020Article
- Inhibition of androgen receptor can decrease fat metabolism by decreasing carnitine palmitoyltransferase I levels in skeletal muscles of trained mice.Nutrition & metabolism · 2019Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeDihydrotestosterone (DHT) plays an important role in various processes that utilize energy, including fat and carbohydrate oxidation. The purpose of this study was to determine the effect of inhibiting DHT formation during mid-intensity running exercise on energy expenditure and fat and carbohydrate oxidation in the whole body using a calorimetric chamber.
methodsTwelve ICR adult male mice, 9 weeks of age, were randomized into two groups: CON (n = 6, no treatment with exercise) and CONIN (n = 6, DHT inhibitor treatment with exercise, SRD5A1A2 is an enzyme involved in the metabolism of free testosterone into DHT). Inhibitor was administered to the CONIN group intraperitoneally, while the CON group was treated with vehicle (corn oil 2 mg/kg). After 3 days of administration of the inhibitor or vehicle, exercise was performed at 60-70% VO2max for 30 min on a treadmill in a calorimetric chamber. The O2 uptake, CO2 production, carbohydrate and fat oxidation, and respiratory exchange ratio (RER) during 30-min exercise were measured using a calorimeter.
resultsDuring a single bout of exercise, the CONIN group showed a significantly higher area under the curve (AUC) of O2 uptake and CO2 production from 20 min into exercise than the CON group (p < 0.001). The CONIN group showed a significantly higher AUC for carbohydrate oxidation from 20 min into exercise than the CON group (p < 0.001), whereas no difference was found in fat oxidation between groups (p = 0.067). The CONIN group had a significantly higher AUC of RER from 20 min into exercise than the CON group (p < 0.001).
conclusionWe observed increased energy consumption at the later phase of 30-min moderate-intensity treadmill running when DHT production was inhibited. Furthermore, when DHT production during exercise was inhibited, whole-body fat utilization was inhibited and carbohydrate oxidation was substantially increased at the later phase of exercise compared to in the control group. Therefore, changes in DHT concentration in the body during exercise may be involved in whole-body fat utilization, suggesting that DHT may be an important factor affecting endurance exercise capacity.
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