Evidence map›Paper›PMID 30148822›Full record

ArticleMedical science monitor : international medical journal of experimental and clinical research2018

Activation of the Nuclear Erythroid 2-Related Factor 2 Antioxidant Responsive Element (Nrf2-ARE) Signaling Pathway Alleviates Acute Graft-Versus-Host Disease by Reducing Oxidative Stress and Inhibiting Infiltration of Inflammatory Cells in an Allogeneic Stem Cell Transplantation Mouse Model.

Ting Yi, Xiaogang Li, Erhua Wang, Yanan Zhang, Yunfeng Fu, Jieping Li, Tiebin Jiang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medical science monitor : international medical journal of experimental and clinical research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
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  3. Review
  4. Article
  5. Review
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  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Ting YiDepartment of Hematology, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China (mainland).
Xiaogang LiDepartment of Cardiology, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China (mainland).
Erhua WangDepartment of Hematology, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China (mainland).
Yanan ZhangDepartment of Hematology, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China (mainland).
Yunfeng FuDepartment of Hematology, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China (mainland).
Jieping LiDepartment of Hematology, Changsha Central Hospital, Changsha, Hunan, China (mainland).
Tiebin JiangDepartment of Hematology, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China (mainland).
Third Xiangya Hospital · CNCentral South University · CNChangsha Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND Acute graft-versus-host disease (aGVHD) limits the wider application of hematopoietic stem cell transplantation (HSCT). We explored the relationship between the Nrf2-ARE signaling pathway and aGVHD and identified effective and efficient therapeutic targets for the prevention and management of aGVHD following HSCT. MATERIAL AND METHODS C57BL/6 and BALB/c mice were used to establish the aGVHD model. The bone marrow and spleen mononuclear cells were separated from the donor mice and injected into the caudal vein of recipient mice that had undergone total body irradiation (TBI, 8 Gy). Sulforaphane (SFN) was used to activate the Nrf2-ARE signaling pathway. RESULTS The long-term survival rate of the SFN group was higher than that of the control group (40% vs. 0%, p<0.05, n=10). There were worse pathological changes and a greater infiltration of inflammatory cells in the liver, small intestine, and lung tissues of the control group. Furthermore, the Nrf2, NQO1, and HO-1 mRNA and protein levels were higher in the small intestines of the SFN group than in the control group (p<0.05, n=4). CONCLUSIONS The Nrf2-ARE signaling pathway plays a vital role in preventing aGVHD in an HSCT mouse model by regulating the expression of the downstream antioxidant genes NQO1 and HO-1 and by inhibiting the local inflammatory reaction.

Indexed as

Antioxidant Response ElementsAnimalsBone Marrow CellsDisease Models, AnimalFemaleGraft vs Host DiseaseHematopoietic Stem Cell TransplantationHeme Oxygenase-1InflammationLeukocytes, MononuclearMaleMembrane ProteinsMiceMice, Inbred BALB CMice, Inbred C57BLNAD(P)H Dehydrogenase (Quinone)Heme Oxygenase-1Hmox1 protein, mouseMembrane ProteinsNAD(P)H Dehydrogenase (Quinone)Nfe2l2 protein, mouseNF-E2-Related Factor 2Nqo1 protein, mouse

Identifiers

PMID30148822
PMCPMC6122273
OpenAlexW2889133027

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.