Evidence map›Paper›PMID 30148686›Full record

ArticleCancer biology & therapy2019

ELF3 is an antagonist of oncogenic-signalling-induced expression of EMT-TF ZEB1.

D Liu, Y Skomorovska, J Song, E Bowler, R Harris, M Ravasz, S Bai, M Ayati, K Tamai, M Koyuturk and 4 more

Open access · hybridAbstract read
In one paragraph

Article in Cancer biology & therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
  2. Article
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  6. Review
  7. Review
  8. FZD5 prevents epithelial-mesenchymal transition in gastric cancer.Cell communication and signaling : CCS · 2021
    Article
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  10. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 3 countries.

D Liua Department of Oncology , Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan , China.
Y Skomorovskac School of Medicine , Case Western Reserve University , Cleveland , Ohio , USA.
J Songc School of Medicine , Case Western Reserve University , Cleveland , Ohio , USA.
E Bowlerb School of Biological Sciences, Faculty of Natural and Environmental Sciences , University of Southampton , Southampton, UK.
R Harrisb School of Biological Sciences, Faculty of Natural and Environmental Sciences , University of Southampton , Southampton, UK.
M Ravaszd School of Biological Sciences , University of Edinburgh , Edinburgh , UK.
S Baic School of Medicine , Case Western Reserve University , Cleveland , Ohio , USA.
M Ayatie Electrical Engineering and Computer Science , Case Western Reserve University , Cleveland , Ohio , USA.
K Tamaic School of Medicine , Case Western Reserve University , Cleveland , Ohio , USA.
M Koyuturke Electrical Engineering and Computer Science , Case Western Reserve University , Cleveland , Ohio , USA.
X Yuana Department of Oncology , Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan , China.
Z Wangc School of Medicine , Case Western Reserve University , Cleveland , Ohio , USA.
Y Wanga Department of Oncology , Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan , China.ORCID 0000-0001-5561-0648
R M Ewingb School of Biological Sciences, Faculty of Natural and Environmental Sciences , University of Southampton , Southampton, UK.ORCID 0000-0001-6510-4001
Case Western Reserve University · USTongji Hospital · CNUniversity of Southampton · GBUniversity of Edinburgh · GB

Funding

Mechanisms of metabolic reprogramming by PIK3CA oncogenic mutationsR01CA196643 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI Zhenghe Wang · 2016 to 2026
$3.1M
Enhancing Genome-Wide Association Studies via Integrative Network AnalysisR01LM011247 · NLM · CASE WESTERN RESERVE UNIVERSITY · PI KOYUTURK, MEHMET · 2012 to 2015
$1.3M
Developing novel technology for mapping dynamic oncoprotein interaction networksR21CA160060 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI WANG, ZHENGHE · 2012 to 2013
$464k
High throughput screen for GPT2 inhibitors to target PIK3CA-mutant cancersUH2CA223670 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI WANG, ZHENGHE · 2018 to 2019
$378k
NCI NIH HHS R01 CA196643NCI NIH HHS R21 CA160060NCI NIH HHS UH2 CA223670NLM NIH HHS R01 LM011247Wellcome Trust
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AdenocarcinomaCell Line, TumorCell Transformation, NeoplasticColorectal NeoplasmsDatasets as TopicDNA-Binding ProteinsEpithelial-Mesenchymal TransitionGene Expression ProfilingGene Expression Regulation, NeoplasticHumansPrognosisProto-Oncogene Proteins c-etsras ProteinsRNA-SeqSurvival AnalysisTissue Array AnalysisDNA-Binding ProteinsELF3 protein, humanProto-Oncogene Proteins c-etsras ProteinsTranscription FactorsZEB1 protein, humanZinc Finger E-box-Binding Homeobox 1epithelial-mesenchymal transitionOncogenic signallingprotein networksRNA-seqWnt signalling

Identifiers

PMID30148686
PMCPMC6292503
OpenAlexW2888907822

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.