Evidence map›Paper›PMID 30148244›Full record

ArticleOphthalmology. Retina2018

Plexus-Specific Detection of Retinal Vascular Pathologic Conditions with Projection-Resolved OCT Angiography.

Rachel C Patel, Jie Wang, Thomas S Hwang, Miao Zhang, Simon S Gao, Mark E Pennesi, Steven T Bailey, Brandon J Lujan, Xiaogang Wang, David J Wilson and 2 more

Abstract read
In one paragraph

Article in Ophthalmology. Retina, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
4.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Advances in OCT Angiography.Translational vision science & technology · 2025
    Review
  3. Article
  4. Article
  5. Article
  6. Artificial intelligence in OCT angiography.Progress in retinal and eye research · 2021
    Review
  7. Article
  8. Optical Coherence Tomography and Glaucoma.Annual review of vision science · 2021
    Review
  9. Artifacts and artifact removal in optical coherence tomographic angiography.Quantitative imaging in medicine and surgery · 2021
    Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Observational
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 2 countries.

Rachel C PatelCasey Eye Institute, Oregon Health & Science University, 3375 SW Terwilliger Blvd, Portland, OR 97239.
Jie WangCasey Eye Institute, Oregon Health & Science University, 3375 SW Terwilliger Blvd, Portland, OR 97239.
Thomas S HwangCasey Eye Institute, Oregon Health & Science University, 3375 SW Terwilliger Blvd, Portland, OR 97239.
Miao ZhangCasey Eye Institute, Oregon Health & Science University, 3375 SW Terwilliger Blvd, Portland, OR 97239.
Simon S GaoCasey Eye Institute, Oregon Health & Science University, 3375 SW Terwilliger Blvd, Portland, OR 97239.
Mark E PennesiCasey Eye Institute, Oregon Health & Science University, 3375 SW Terwilliger Blvd, Portland, OR 97239.
Steven T BaileyCasey Eye Institute, Oregon Health & Science University, 3375 SW Terwilliger Blvd, Portland, OR 97239.
Brandon J LujanCasey Eye Institute, Oregon Health & Science University, 3375 SW Terwilliger Blvd, Portland, OR 97239.
Xiaogang WangCasey Eye Institute, Oregon Health & Science University, 3375 SW Terwilliger Blvd, Portland, OR 97239.
David J WilsonCasey Eye Institute, Oregon Health & Science University, 3375 SW Terwilliger Blvd, Portland, OR 97239.
David HuangCasey Eye Institute, Oregon Health & Science University, 3375 SW Terwilliger Blvd, Portland, OR 97239.
Yali JiaCasey Eye Institute, Oregon Health & Science University, 3375 SW Terwilliger Blvd, Portland, OR 97239.
Oregon Health & Science University · US

Funding

Proteomics CoreP30EY010572 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Kate E Keller · 1995 to 2026
$19.4M
Functional and Structural Optical Coherence Tomography for GlaucomaR01EY023285 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI David Huang · 2013 to 2026
$8.8M
OCT Angiography for Neovascular Age-related Macular DegenerationR01EY024544 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Steven T Bailey, Yali Jia · 2014 to 2026
$6.2M
Wide-field and projection-resolved optical coherence tomography angiography in diabetic retinopathyR01EY027833 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI HWANG, THOMAS, JIA, YALI · 2017 to 2020
$1.8M
Functional Optical Coherence Tomography-derived Biomarkers for Diabetic RetinopathyDP3DK104397 · NIDDK · OREGON HEALTH & SCIENCE UNIVERSITY · PI JIA, YALI, WILSON, DAVID J · 2014 to 2014
$1.0M
NEI NIH HHS P30 EY010572NEI NIH HHS R01 EY023285NEI NIH HHS R01 EY024544NEI NIH HHS R01 EY027833NIDDK NIH HHS DP3 DK104397
6 · The paper itself

Abstract

objectiveTo evaluate the projection-resolved (PR) optical coherence tomography angiography (OCTA) algorithm in detecting plexus-specific vascular abnormalities in retinal pathologies.

designCross-sectional observational clinical study.

participantsPatients diagnosed with retinal vascular diseases and healthy volunteers.

methodsEyes were imaged using an OCT system operating at 840 nm and employing the split-spectrum amplitude decorrelation algorithm. A novel algorithm suppressed projection artifacts inherent to OCTA. The volumetric scans were segmented and visualized on different plexuses.

main outcome measuresQualitative observation of vascular abnormalities on both cross-sectional and

resultsEight illustrative cases are reported. In cases of diabetic retinopathy, retinal vessel occlusion, and retinitis pigmentosa, PR-OCTA detected retinal nonperfusion regions within deeper retinal plexuses not visualized by conventional OCTA. In age-related macular degeneration, cross-sectional PR-OCTA permitted the classification of choroidal neovascularization, and, in a case of retinal angiomatous proliferation, identified a vertical vessel contiguous with the deep capillary plexus. In macular telangiectasia, PR-OCTA detected a diving perifoveal vein and delineated subretinal neovascularization.

conclusionsApplication of PR-OCTA promises to improve sensitive, accurate evaluation of individual vascular plexuses in multiple retinal diseases.

Identifiers

PMID30148244
PMCPMC6106769
OpenAlexW2782618755

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.