ReviewWorld journal of clinical cases2018
Risk factors for gastroesophageal reflux disease and analysis of genetic contributors.
Review in World journal of clinical cases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed, 1 synthesis or guideline pooled it, 111 citations in OpenAlex.
- GERD and Upper Aerodigestive Tract Cancer Risk: A Systematic Review and Meta-Analysis.The Laryngoscope · 2026Pooled it
- Gastric subepithelial lesions located within the trajectory of clasp and sling fibers are associated with increased prevalence and severity of reflux esophagitis.Surgical endoscopy · 2026Article
- Gastroesophageal reflux disease and temporomandibular disorder risk: a nationwide cohort study.BMC oral health · 2026Article
- Early-Life and Psychosocial Factors in Adults with Symptoms Consistent with Retrograde Cricopharyngeus Dysfunction.Journal of clinical medicine · 2026Article
- Perceived stress, diet, and medication use associated with GERD symptoms in Lebanese adults: A cross-sectional study.Journal of public health research · 2026Article
- Immune functions of the esophagus.The Journal of allergy and clinical immunology · 2026Review
- Article
- Diagnostic accuracy of gastric filling ultrasound combined with BMI for gastroesophageal reflux disease.Frontiers in medicine · 2026Article
- Introducing Prostaglandin Endoperoxide Synthase-2 as a Remarkable Player in the Development of Gastroesophageal Reflux Disease.Medical journal of the Islamic Republic of Iran · 2026Article
- Laryngopharyngeal Reflux: The Impact of Obesity.World journal of otorhinolaryngology - head and neck surgery · 2025Article
- Gene-Diet interaction between FTO rs9939609 and fiber intake in relation to GERD susceptibility.Molecular biology reports · 2025Article
- Mild to moderate GERD before sleeve: Can we better predict post-operative GERD?Surgical endoscopy · 2025Article
- Does Mean Nocturnal Baseline Impedance Play a Role in Managing Gastroesophageal Reflux Disease?Journal of neurogastroenterology and motility · 2025Article
- Global burden of esophageal diseases: a comprehensive analysis of disease trends and risk factors from 1990 to 2021.BMC gastroenterology · 2025Article
- Association between wet-bulb globe temperature with gastroesophageal reflux disease in different geographic regions in a large Taiwanese population study.Scientific reports · 2025Article
- Prevalence of GERD Symptoms and its Related Risk Factors Among Medical Students in Saudi Arabia.Journal of pharmacy & bioallied sciences · 2025Article
- Exploring the genetic link between gastroesophageal reflux disease and pancreatic cancer: insights from Mendelian randomization.BMC cancer · 2025Article
- Association between an energy-adjusted inflammatory diet index and gastroesophageal reflux disease: a retrospective cohort study.European journal of nutrition · 2025Article
- Insight into global burden of gastroesophageal reflux disease: Understanding its reach and impact.World journal of gastrointestinal pharmacology and therapeutics · 2025Review
- Novel risk loci encompassing genes influencing STAT3, GPCR, and oxidative stress signaling are associated with co-morbid GERD and COPD.PLoS genetics · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gastroesophageal reflux disease (GERD) is a common gastrointestinal disorder with an increasing prevalence. GERD develops when the reflux of stomach contents causes troublesome typical and atypical symptoms and/or complications. Several risk factors of GERD have been identified and evaluated over the years, including a considerable amount of genetic factors. Multiple mechanisms are involved in the pathogenesis of GERD including: (1) motor abnormalities, such as impaired lower esophageal sphincter (LES) resting tone, transient LES relaxations, impaired esophageal acid clearance and delayed gastric emptying; and (2) anatomical factors, such as hiatal hernia and obesity. Genetic contribution seems to play a major role in GERD and GERD- related disorders development such Barrett's esophagus and esophageal adenocarcinoma. Twin and family studies have revealed an about 31% heritability of the disease. Numerous single-nucleotide polymorphisms in various genes like
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.