ArticleIndian journal of endocrinology and metabolism
Clonidine Stimulation Test: Is Single Best Time Point, Convenient Yet Efficacious?
Article in Indian journal of endocrinology and metabolism. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Article
- L-DOPA Test in the Diagnosis of Childhood Short Stature: Evaluation of Growth Hormone Peaks Over Time.Endocrinology, diabetes & metabolism · 2024Article
- Reliability of Agreement between Insulin, Clonidine, and Glucagon Stimulation Tests for the Diagnosis of Growth Hormone Deficiency in Children: A Retrospective Cohort Study.Children (Basel, Switzerland) · 2023Article
- Use of the Growth Hormone Stimulation Test Result in the Management of Patients With a Short Stature.Cureus · 2020Article
- What Is the Best Regimen for Ovarian Stimulation of Poor Responders in ART/IVF?Frontiers in endocrinology · 2020Review
- Growth Hormone Stimulation: An Achilles Heel in the Evaluation of Short Stature.Indian journal of endocrinology and metabolismArticle
- Pragmatic Evaluation of Growth Hormone Stimulation Tests in Short Stature.Indian journal of endocrinology and metabolismArticle
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Authors and funding
8 authors.
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Abstract
contextTo find a single time point during clonidine stimulation test (CST), with highest diagnostic value to rule out growth hormone deficiency (GHD). SETTINGS AND
designThis is a retrospective study of 79 CSTs carried out in a tertiary care center in India. MATERIALS AND
methodsA cohort of 79 children with unexplained short stature was divided into two groups: GHD and non-GHD. Any one stimulated growth hormone (GH) level >10 ng/mL was used to rule out GHD. Diagnostic accuracy of not only single time points but also time points in pairs was calculated. STATISTICAL ANALYSIS: The data were analyzed using SPSS statistical software 22.0. Descriptive statistics were used for analyzing demographic data. Mode for time to peak GH was calculated in each group. The specificity and false positive rates at each time point as well as combined time points were determined.
resultsAssaying a single sample at 60 min after clonidine resulted in 20.5% false positive tests with specificity of 79.5%. Addition of the 90 min sample increased specificity to 92.3%.
conclusionThe 60 min sample after clonidine stimulation was the best single sample to rule out GH deficiency. Combined sampling at 60 min + 90 min is economical and less cumbersome, with minimal compromise on the specificity.
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