ArticleNeuroImage. Clinical2018
White matter network topology relates to cognitive flexibility and cumulative neurological risk in adult survivors of pediatric brain tumors.
Article in NeuroImage. Clinical, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Graph Theoretical Analysis of Brain Network Characteristics in Brain Tumor Patients: A Systematic Review.Neuropsychology review · 2022Pooled it
- Executive function after childhood cancer: Insights from network neuroscience.Neuro-oncology advances · 2026Review
- Altered structural networks and cognitive functioning in long-term survivors of pediatric brain tumors.Neuroimage. Reports · 2026Article
- Neuropsychological function in childhood cancer patients and adult survivors of childhood cancer.Journal of clinical and experimental neuropsychology · 2025Review
- Increased functional network segregation in glioma patients posttherapy: A neurological compensatory response or catastrophe for cognition?Network neuroscience (Cambridge, Mass.) · 2025Article
- Seeing through "brain fog": neuroimaging assessment and imaging biomarkers for cancer-related cognitive impairments.Cancer imaging : the official publication of the International Cancer Imaging Society · 2024Review
- White matter connectivity and social functioning in survivors of pediatric brain tumor.Journal of neuro-oncology · 2024Article
- Brain network topology and its cognitive impact in adult glioma survivors.Scientific reports · 2024Article
- Graph analysis of resting state functional brain networks and associations with cognitive outcomes in survivors of pediatric brain tumor.Neuroimage. Reports · 2023Article
- Elucidating the structural-functional connectome of language in glioma-induced aphasia using nTMS and DTI.Human brain mapping · 2022Article
- Network analysis shows decreased ipsilesional structural connectivity in glioma patients.Communications biology · 2022Article
- Functional network alterations in young brain tumor patients with radiotherapy-induced memory impairments and vascular injury.Frontiers in neurology · 2022Article
- Cerebellar-Subcortical-Cortical Systems as Modulators of Cognitive Functions.Neuropsychology review · 2021Review
- Brain Imaging in Pediatric Cancer Survivors: Correlates of Cognitive Impairment.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2021Review
- Impact of non-CNS childhood cancer on resting-state connectivity and its association with cognition.Brain and behavior · 2021Article
- Diminished social attention in pediatric brain tumor survivors: Using eye tracking technology during naturalistic social perception.Neuropsychology · 2020Article
- Neurological predictor scale is associated with academic achievement outcomes in long-term survivors of childhood brain tumors.Journal of neuro-oncology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Adult survivors of pediatric brain tumors exhibit deficits in executive functioning. Given that brain tumors and medical treatments for brain tumors result in disruptions to white matter, a network analysis was used to explore the topological properties of white matter networks. This study used diffusion tensor imaging and deterministic tractography in 38 adult survivors of pediatric brain tumors (mean age in years = 23.11 (SD = 4.96), 54% female, mean years post diagnosis = 14.09 (SD = 6.19)) and 38 healthy peers matched by age, gender, handedness, and socioeconomic status. Nodes were defined using the Automated Anatomical Labeling (AAL) parcellation scheme, and edges were defined as the mean fractional anisotropy of streamlines that connected each node pair. Global efficiency and average clustering coefficient were reduced in survivors compared to healthy peers with preferential impact to hub regions. Global efficiency mediated differences in cognitive flexibility between survivors and healthy peers, as well as the relationship between cumulative neurological risk and cognitive flexibility. These results suggest that adult survivors of pediatric brain tumors, on average one and a half decades post brain tumor diagnosis and treatment, exhibit altered white matter topology in the form of suboptimal integration and segregation of large scale networks, and that disrupted topology may underlie executive functioning impairments. Network based studies provided important topographic insights on network organization in long-term survivors of pediatric brain tumor.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.