Evidence map›Paper›PMID 30148053›Full record

ArticleMedical mycology case reports2018

The treatment of a pregnant HIV positive patient with cryptococcal meningitis in Malawi. Case report and review of treatment options.

Philip D Bright, Duncan Lupiya, Joep J van Oosterhout, Amy Chen, Thomas S Harrison, Adrienne K Chan

Open access · goldAbstract read
In one paragraph

Article in Medical mycology case reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 2 pooled it
0.3field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 syntheses or guidelines pooled it, 7 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 3 countries.

Philip D BrightInstitute of Infection and Immunity, St Georges University of London, Cranmer Terrace, London SW17 0RE, United Kingdom.
Duncan LupiyaDignitas International, Zomba, Malawi.
Joep J van OosterhoutDignitas International, Zomba, Malawi.
Amy ChenTrillium Health Partners, University of Toronto, Canada.
Thomas S HarrisonInstitute of Infection and Immunity, St Georges University of London, Cranmer Terrace, London SW17 0RE, United Kingdom.
Adrienne K ChanDignitas International, Zomba, Malawi.
St George's, University of London · GBDignitas International · MWHealth Sciences Centre · CATrillium Health Centre · CAUniversity of Malawi · MW

Funding

Medical Research Council G1100814
6 · The paper itself

Abstract

This case reports cryptococcal meningitis in an HIV positive woman on antiretroviral therapy, presenting with left middle cerebral artery stroke at 30 weeks gestation. The patient had well-controlled HIV (CD4 count over 200 cells/mL). The immunosuppressive effects of the pregnancy likely contributed to the development of cryptococcal disease. The patient was successfully treated with two weeks of amphotericin B followed by fluconazole, delivered a healthy baby, but remained with a permanent severe neurological deficit.

Indexed as

Cryptococcal meningitisHIVMalawiPregnancyTreatment

Identifiers

PMID30148053
PMCPMC6105915
OpenAlexW2766749408

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.