ArticleOxidative medicine and cellular longevity2018
Lycopene: Hepatoprotective and Antioxidant Effects toward Bisphenol A-Induced Toxicity in Female Wistar Rats.
Article in Oxidative medicine and cellular longevity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Therapeutic Effect of Natural Products and Dietary Supplements on Aflatoxin-Induced Nephropathy.International journal of molecular sciences · 2024Pooled it
- Plasma proteome profiling identifies XPNPEP3 as a novel biomarker associated with metabolic dysfunction-associated steatotic liver disease in patients with type 2 diabetes mellitus.Annals of medicine · 2026Article
- Differential responses of Citrus species to Huanglongbing infection for physiological, biochemical, nutritional, bio-stress enzymes, and molecular markers.Scientific reports · 2026Article
- A comprehensive review of medicinal plants and their beneficial roles in alleviating bisphenol A-induced organ toxicity.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- The impact of enriching heat-stressed rabbit diets with flaxseed oil with/ without allicin, lycopene, or Punicalagin on antioxidative status, physiological response and meat omega-3.BMC veterinary research · 2025Article
- Erythrosine-induced hepatic biomarkers and histopathological changes in male rats: protective effects of lycopene and anthocyanin.Frontiers in pharmacology · 2025Article
- Significant Microbial Pathogenesis Perspective of Biliary Diseases.Infectious disorders drug targets · 2025Review
- Lycopene alleviates 5-fluorouracil-induced nephrotoxicity by modulating PPAR-γ, Nrf2/HO-1, and NF-κB/TNF-α/IL-6 signals.Renal failure · 2024Article
- Polyphenols Regulate the Activity of Endocrine-Disrupting Chemicals, Having Both Positive and Negative Effects.Journal of xenobiotics · 2024Review
- Lycopene improves autophagy and attenuates carbon tetrachloride-induced hepatic fibrosis in rats.Croatian medical journal · 2023Article
- Re-evaluation of the risks to public health related to the presence of bisphenol A (BPA) in foodstuffs.EFSA journal. European Food Safety Authority · 2023Article
- Lycopene Improves Metabolic Disorders and Liver Injury Induced by a Hight-Fat Diet in Obese Rats.Molecules (Basel, Switzerland) · 2022Article
- Natural Products in Mitigation of Bisphenol A Toxicity: Future Therapeutic Use.Molecules (Basel, Switzerland) · 2022Review
- Exposure to Bisphenol A Caused Hepatoxicity and Intestinal Flora Disorder in Rats.International journal of molecular sciences · 2022Article
- Can Antioxidants Reduce the Toxicity of Bisphenol?Antioxidants (Basel, Switzerland) · 2022Review
- Protective impact of lycopene on ethinylestradiol-induced cholestasis in rats.Naunyn-Schmiedeberg's archives of pharmacology · 2021Article
- Bisphenol A and Bisphenol S Oxidative Effects in Sheep Red Blood Cells: AnBioMed research international · 2021Article
- Ameliorative effects of crocin on tartrazine dye-induced pancreatic adverse effects: a biochemical and histological study.Environmental science and pollution research international · 2021Article
- Bisphenol A in utero exposure induces ovary dysfunction in mice offspring and the ameliorating effects of Cuscuta chinensis flavonoids.Environmental science and pollution research international · 2020Article
- Genome-Protecting Compounds as Potential Geroprotectors.International journal of molecular sciences · 2020Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bisphenol A (BPA)-an endocrine disruptor xenoestrogen-is widely spread in the environment. Lycopene (LYC) is an antioxidant phytochemical carotenoid. The hereby study was designed to verify the deleterious effect of BPA on cyclic female rats' hepatic tissue as well as evaluation of the effect of LYC toward BPA hepatic perturbation. Twenty-eight female Wistar rats were allocated equally into four groups: control group, LYC group (10 mg/kg B.wt), BPA group (10 mg/kg B.wt), and BPA + LYC group (the same doses as former groups). The treatments were given daily via gavage to the rats for 30 days. The rats in BPA displayed high activities of serum liver enzymes with low levels of total proteins (TP) and albumin. Moreover, BPA induced hepatic oxidative stress via depletion of antioxidant enzymes concomitant with augmentation of lipid peroxidation, increased comet tail DNA %, and overexpression of caspase-3. Meanwhile, LYC administration reduced the cytotoxic effects of BPA on hepatic tissue, through improving the liver function biomarkers and oxidant-antioxidant state as well as DNA damage around the control values. These findings were confirmed by hepatic histopathological examination. Finally, LYC credited to have a noticeable protective effect versus BPA provoked oxidative injury and apoptosis of the liver tissue.
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