Evidence map›Paper›PMID 30147718›Full record

ArticleNeural plasticity2018

Reorganization of the Action Observation Network and Sensory-Motor System in Children with Unilateral Cerebral Palsy: An fMRI Study.

Giuseppina Sgandurra, Laura Biagi, Leonardo Fogassi, Elisa Sicola, Adriano Ferrari, Andrea Guzzetta, Michela Tosetti, Giovanni Cioni

Registry-linked trialAbstract read
In one paragraph

Article in Neural plasticity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04759690 (Effects of Action Observation Training Combined With Exercises on Balance and Risk of Fall Over 65 Years Old), which is not on this map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04759690 nacompletednot on this mapstarted 2020, after this paper: background citation

Effects of Action Observation Training Combined With Exercises on Balance and Risk of Fall Over 65 Years Old

TypeinterventionalSponsorIstanbul Medipol University HospitalRan2020 to 2021Enrolled43ConditionsFall Prevention, ElderlyArmsAction observation, Exercise group
3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Giuseppina SgandurraDepartment of Developmental Neuroscience, IRCCS Fondazione Stella Maris, Calambrone, Pisa, Italy.ORCID 0000-0003-1081-1766
Laura BiagiLaboratory of Medical Physics and Biotechnologies for Magnetic Resonance, IRCCS Fondazione Stella Maris, Calambrone, Pisa, Italy.ORCID 0000-0003-2159-439X
Leonardo FogassiDepartment of Neuroscience, University of Parma and Istituto Italiano di Tecnologia (RTM), Parma, Italy.ORCID 0000-0003-3348-039X
Elisa SicolaDepartment of Developmental Neuroscience, IRCCS Fondazione Stella Maris, Calambrone, Pisa, Italy.
Adriano FerrariIRCCS S. Maria Nuova Hospital, Reggio Emilia, Italy.ORCID 0000-0002-6166-1350
Andrea GuzzettaDepartment of Developmental Neuroscience, IRCCS Fondazione Stella Maris, Calambrone, Pisa, Italy.ORCID 0000-0003-3868-0059
Michela TosettiLaboratory of Medical Physics and Biotechnologies for Magnetic Resonance, IRCCS Fondazione Stella Maris, Calambrone, Pisa, Italy.ORCID 0000-0002-2515-7560
Giovanni CioniDepartment of Developmental Neuroscience, IRCCS Fondazione Stella Maris, Calambrone, Pisa, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Little is known about the action observation network (AON) in children with unilateral cerebral palsy (UCP). Using fMRI, we aimed to explore AON and sensory-motor network (SMN) in UCP children and compare them to typically developed (TD) children and analyse the relationship between AON (re-)organization and several neurophysiological and clinical measures. Twelve UCP children were assessed with clinical scales and transcranial magnetic stimulation (TMS). For the fMRI study, they underwent a paradigm based on observation of complex and simple object-manipulation tasks executed by dominant and nondominant hand. Moreover, UCP and TD children carried out a further fMRI session to explore SMN in both an active motor and passive sensory task. AON in the UCP group showed higher lateralization, negatively related to performances on clinical scales, and had greater activation of unaffected hemisphere as compared to the bilateral representation in the TD group. In addition, a good congruence was found between bilateral or contralateral activation of AON and activation of SMN and TMS data. These findings indicate that our paradigm might be useful in exploring AON and the response to therapy in UCP subjects.

Indexed as

Neuronal PlasticityAdolescentBrainBrain MappingCerebral PalsyChildFemaleFunctional LateralityHumansMagnetic Resonance ImagingMaleMotion PerceptionNeural PathwaysPattern Recognition, VisualSensorimotor CortexTranscranial Magnetic Stimulation

Identifiers

PMID30147718
PMCPMC6083552

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.