Evidence map›Paper›PMID 30147641›Full record

ArticleFrontiers in neuroscience2018

Cory Richman, Sabih Rashid, Shreya Prashar, Ram Mishra, P Ravi Selvaganapathy, Bhagwati P Gupta

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. The neurotrophic factor MANF regulates autophagy and lysosome function to promote proteostasis inProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
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  7. Article
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  11. Article
  12. UPR Responsive GenesFrontiers in cellular neuroscience · 2022
    Review
  13. Therapeutic effects of TP5, a Cdk5/p25 inhibitor, inCurrent research in neurobiology · 2021
    Article
  14. Review
  15. Review
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  17. Article
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Cory RichmanDepartment of Biology, McMaster University, Hamilton, ON, Canada.
Sabih RashidDepartment of Biology, McMaster University, Hamilton, ON, Canada.
Shreya PrasharDepartment of Biology, McMaster University, Hamilton, ON, Canada.
Ram MishraDepartment of Psychiatry and Behavioural Neuroscience, McMaster University, Hamilton, ON, Canada.
P Ravi SelvaganapathyDepartment of Mechanical Engineering, McMaster University, Hamilton, ON, Canada.
Bhagwati P GuptaDepartment of Biology, McMaster University, Hamilton, ON, Canada.
McMaster University · CA

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
NIH HHS P40 OD010440
6 · The paper itself

Abstract

Neurotrophic factors (NTFs) are important for the development, function, and survival of neurons in the mammalian system. Mesencephalic astrocyte-derived neurotrophic factor (MANF) and cerebral dopamine neurotrophic factor (CDNF) are two recently identified members of a novel family of NTFs in vertebrates that function to protect dopaminergic neurons. Although these genes are conserved across eukaryotes, their mechanism of neuroprotection is not fully understood. Sequence searches for MANF/CDNF homologs in invertebrates have identified a single ortholog that is most related to MANF. Here we report the

Indexed as

CDNFC. elegansdopamineER stressMANFmanf-1neurodegenerationParkinson's disease

Identifiers

PMID30147641
PMCPMC6095968
OpenAlexW2886202418

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.