ArticleCancer management and research2018
Proximal shift of colorectal cancer with increasing age in different ethnicities.
Article in Cancer management and research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 17 citations in OpenAlex.
- Epidemiology of colonic adenoma and cancer.Clinical endoscopy · 2026Review
- The Old: Is There Any Role for Screening Colonoscopy after the Age of 75? The Surgeon's Perspective.Clinics in colon and rectal surgery · 2025Review
- Immune-Related Adverse Events and Survival Among Patients With Metastatic NSCLC Treated With Immune Checkpoint Inhibitors.JAMA network open · 2024Observational
- Article
- Changing Colorectal Cancer Trends in Asians: Epidemiology and Risk Factors.Oncology reviews · 2023Review
- Metastatic Colorectal Cancer Outcomes by Age Among ARCAD First- and Second-Line Clinical Trials.JNCI cancer spectrum · 2022Article
- Global colorectal cancer burden in 2020 and projections to 2040.Translational oncology · 2021Review
- Review
- Clinical characteristics of patients in their forties who underwent surgical resection for colorectal cancer in Korea.World journal of gastroenterology · 2021Article
- Emerging trends in colorectal cancer: Dysregulated signaling pathways (Review).International journal of molecular medicine · 2021Article
- Global burden of colorectal cancer: emerging trends, risk factors and prevention strategies.Nature reviews. Gastroenterology & hepatology · 2019Review
- In elderly population prophylactic anticoagulation favors early detection of digestive track cancers: an observational study in eastern Poland.Journal of geriatric cardiology : JGC · 2019Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStudies have indicated a variation in colon cancer pathology with increased age. More findings have also suggested differences in genetics, biology, and demography in terms of ethnicity. Large-scale studies closely examining tumor location shift with aging and ethnicity are scarce.
objectiveWe compared the tumor location shift with aging and the difference in survival based on tumor location by age group among the African-American, White, and Asian/Pacific Islander patients with colorectal cancer. MATERIALS AND
methodsWe collected 270,390 cases from the Surveillance, Epidemiology, and End Results database between 2004 and 2014. Ethnicity distribution between younger (age <70 years) and older (age ≥70 years) patients was analyzed using univariate and multivariate logistic regression. The Kaplan-Meier method was used to compare the tumor location survival difference in the African-American, White, and Asian/Pacific Islander patients.
resultsLarger tumors, female sex, M0, advanced N stage, no treatment, moderate to poor differentiation, total number of lymph nodes evaluated >12, and right-sided colon cancer were more common in patients aged ≥70 years. More adverse prognosis was found in younger patients compared to older patients. Tumor location frequency differed based on age; the most pronounced differences were found in White patients. The right-sided colon cancer survival inferiority was present only in White patients.
conclusionOur findings support the premise of etiological and carcinogenic differences based on tumor location and between younger and older patients.
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