Evidence map›Paper›PMID 30147314›Full record

ArticleInternational journal of nanomedicine2018

Matrix metalloproteinase 2/9-triggered-release micelles for inhaled drug delivery to treat lung cancer: preparation and in vitro/in vivo studies.

Xiaofei Wang, Qinyue Chen, Xiaoyan Zhang, Xiaoqing Ren, Xiulei Zhang, Lin Meng, Huihui Liang, Xianyi Sha, Xiaoling Fang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of nanomedicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 34 citations in OpenAlex.

  1. Nanoparticle-Based Pulmonary Immune Engineering.Annual review of chemical and biomolecular engineering · 2025
    Review
  2. Review
  3. Review
  4. Review
  5. Aerosol pulmonary immune engineering.Advanced drug delivery reviews · 2023
    Review
  6. Article
  7. Review
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Xiaofei WangKey Laboratory of Smart Drug Delivery, Ministry of Education of China, School of Pharmacy, Fudan University, Shanghai, People's Republic of China, xlfang@shmu.edu.cn; shaxy@fudan.edu.cn.
Qinyue ChenKey Laboratory of Smart Drug Delivery, Ministry of Education of China, School of Pharmacy, Fudan University, Shanghai, People's Republic of China, xlfang@shmu.edu.cn; shaxy@fudan.edu.cn.
Xiaoyan ZhangKey Laboratory of Smart Drug Delivery, Ministry of Education of China, School of Pharmacy, Fudan University, Shanghai, People's Republic of China, xlfang@shmu.edu.cn; shaxy@fudan.edu.cn.
Xiaoqing RenKey Laboratory of Smart Drug Delivery, Ministry of Education of China, School of Pharmacy, Fudan University, Shanghai, People's Republic of China, xlfang@shmu.edu.cn; shaxy@fudan.edu.cn.
Xiulei ZhangKey Laboratory of Smart Drug Delivery, Ministry of Education of China, School of Pharmacy, Fudan University, Shanghai, People's Republic of China, xlfang@shmu.edu.cn; shaxy@fudan.edu.cn.
Lin MengKey Laboratory of Smart Drug Delivery, Ministry of Education of China, School of Pharmacy, Fudan University, Shanghai, People's Republic of China, xlfang@shmu.edu.cn; shaxy@fudan.edu.cn.
Huihui LiangKey Laboratory of Smart Drug Delivery, Ministry of Education of China, School of Pharmacy, Fudan University, Shanghai, People's Republic of China, xlfang@shmu.edu.cn; shaxy@fudan.edu.cn.
Xianyi ShaKey Laboratory of Smart Drug Delivery, Ministry of Education of China, School of Pharmacy, Fudan University, Shanghai, People's Republic of China, xlfang@shmu.edu.cn; shaxy@fudan.edu.cn.
Xiaoling FangKey Laboratory of Smart Drug Delivery, Ministry of Education of China, School of Pharmacy, Fudan University, Shanghai, People's Republic of China, xlfang@shmu.edu.cn; shaxy@fudan.edu.cn.
Fudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundImprovement in drug accumulation in the lungs through inhalation administration and high expression of MMP2 and MMP9 in lung tumors have both been widely reported.

methodsMMP2/9-triggered-release micelles were constructed and in vitro and in vivo studies of inhalation administration against lung tumor carried out. Pluronic P123 (P123) was modified with GPLGIAGQ-NH2 (GQ8) peptide to obtain P123-GQ8 (PG). MMP2/9-triggered-release micelles were constructed using PG and succinylated gelatin (SG) and loading paclitaxel (Ptx). To study biodistribution of micelles, DiR encapsulated in micelles was dosed to rats via intravenous injection or inhalation before ex vivo imaging for detecting DiR quantity in lungs. And B16F10 lung cancer-bearing nude mice were chosen as animal models to evaluate in vivo efficacy of MMP2/9-triggered-release micelles.

resultsPtx-release efficiency from PG-SG-Ptx micelles was MMP2/9-concentration-dependent. For A549 cells, PG-SG-Ptx cytotoxicity was significantly greater (

conclusionInhalation of MMP2/9-triggered-release micelles increased tumor sensitivity to chemotherapeutics and reduced the toxicity of chemotherapy to healthy lung cells, which has great potential in lung cancer therapy.

Indexed as

MicellesAdministration, InhalationAnimalsAntineoplastic AgentsAntineoplastic Agents, PhytogenicCell Line, TumorDrug Delivery SystemsDrug LiberationEndocytosisFemaleHumansHuman Umbilical Vein Endothelial CellsInjectionsLung NeoplasmsMaleMatrix Metalloproteinase 2Antineoplastic AgentsAntineoplastic Agents, PhytogenicMatrix Metalloproteinase 2Matrix Metalloproteinase 9MicellesPaclitaxelPeptidesinhalationmatrix metalloproteinasespaclitaxelP-glycoproteinPluronic

Identifiers

PMID30147314
PMCPMC6095127
OpenAlexW2886708997

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.