Evidence map›Paper›PMID 30146714›Full record

ArticleMagnetic resonance in medicine2019

Accelerating chemical exchange saturation transfer MRI with parallel blind compressed sensing.

Huajun She, Joshua S Greer, Shu Zhang, Bian Li, Jochen Keupp, Ananth J Madhuranthakam, Ivan E Dimitrov, Robert E Lenkinski, Elena Vinogradov

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Dynamic glucose-enhanced MRI in brain tumors.Magma (New York, N.Y.) · 2026
    Review
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  7. JointTomography (Ann Arbor, Mich.) · 2024
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  11. Article
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  14. Quantitative imaging in medicine and surgery · 2019
    Article
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  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Huajun SheInstitute for Medical Imaging Technology, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Joshua S GreerRadiology, University of Texas Southwestern Medical Center, Dallas, Texas.
Shu ZhangRadiology, University of Texas Southwestern Medical Center, Dallas, Texas.
Bian LiRadiology, University of Texas Southwestern Medical Center, Dallas, Texas.
Jochen KeuppPhilips Research, Hamburg, Germany.
Ananth J MadhuranthakamRadiology, University of Texas Southwestern Medical Center, Dallas, Texas.
Ivan E DimitrovRadiology, University of Texas Southwestern Medical Center, Dallas, Texas.
Robert E LenkinskiRadiology, University of Texas Southwestern Medical Center, Dallas, Texas.
Elena VinogradovRadiology, University of Texas Southwestern Medical Center, Dallas, Texas.

Funding

Endogenous Urea CEST MRI (urCEST): pH and urea gradient mapping in human kidneyR21EB020245 · NIBIB · UT SOUTHWESTERN MEDICAL CENTER · PI VINOGRADOV, ELENA · 2016 to 2017
$445k
Cancer Prevention and Research Institute of TexasCPRIT RP180031Foundation for the National Institutes of HealthNIBIB NIH HHS R21 EB020245NIH HHS R21 EB020245University of Texas Southwestern Radiology Research fundUT Southwestern Medical Center Radiology Research Fund
6 · The paper itself

Abstract

purposeChemical exchange saturation transfer is a novel and promising MRI contrast method, but it can be time-consuming. Common parallel imaging methods, like SENSE, can lead to reduced quality of CEST. Here, parallel blind compressed sensing (PBCS), combining blind compressed sensing (BCS) and parallel imaging, is evaluated for the acceleration of CEST in brain and breast.

methodsThe CEST data were collected in phantoms, brain (N = 3), and breast (N = 2). Retrospective Cartesian undersampling was implemented and the reconstruction results of PBCS-CEST were compared with BCS-CEST and k-t sparse-SENSE CEST. The normalized RMSE and the high-frequency error norm were used for quantitative comparison.

resultsIn phantom and in vivo brain experiments, the acceleration factor of R = 10 (24 k-space lines) was achieved and in breast R = 5 (30 k-space lines), without compromising the quality of the PBCS-reconstructed magnetization transfer rate asymmetry maps and Z-spectra. Parallel BCS provides better reconstruction quality when compared with BCS, k-t sparse-SENSE, and SENSE methods using the same number of samples. Parallel BCS overperforms BCS, indicating that the inclusion of coil sensitivity improves the reconstruction of the CEST data.

conclusionThe PBCS method accelerates CEST without compromising its quality. Compressed sensing in combination with parallel imaging can provide a valuable alternative to parallel imaging alone for accelerating CEST experiments.

Indexed as

Magnetic Resonance ImagingAlgorithmsBrainBreastContrast MediaData CompressionFemaleHumansImage EnhancementImage Interpretation, Computer-AssistedImage Processing, Computer-AssistedMaleNormal DistributionPhantoms, ImagingReproducibility of ResultsContrast Mediablind compressed sensingCESTCEST accelerationparallel blind compressed sensingparallel imaging

Identifiers

PMID30146714
PMCPMC6497066

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.