Evidence map›Paper›PMID 30146675›Full record

ReviewNeuroscience bulletin2019

Cellular and Molecular Mechanisms Underlying Arterial Baroreceptor Remodeling in Cardiovascular Diseases and Diabetes.

Huiyin Tu, Dongze Zhang, Yu-Long Li

Open access · bronzeAbstract readReview
In one paragraph

Review in Neuroscience bulletin, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 32 citations in OpenAlex.

  1. Identification of putative baroreceptors in human aortic arch by histological and omics analyses.Hypertension research : official journal of the Japanese Society of Hypertension · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Huiyin TuDepartment of Emergency Medicine, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Dongze ZhangDepartment of Emergency Medicine, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Yu-Long LiDepartment of Emergency Medicine, University of Nebraska Medical Center, Omaha, NE, 68198, USA. yulongli@unmc.edu.
University of Nebraska Medical Center · US

Funding

Mechanisms of cardiac sympathetic hyperactivity in chronic heart failureR01HL137832 · NHLBI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Yu-Long Li · 2017 to 2026
$4.1M
Potential therapies to improve ventricular vagal function in type 2 diabetesR01HL144146 · NHLBI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI LI, YU-LONG · 2018 to 2021
$1.5M
Dysfunction of Baroreceptor Neurons in Heart Failure: Cellular and Molecular MechR01HL098503 · NHLBI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI LI, YU-LONG · 2010 to 2013
$1.5M
NHLBI NIH HHS R01 HL098503NHLBI NIH HHS R01 HL137832NHLBI NIH HHS R01 HL144146
6 · The paper itself

Abstract

Clinical trials and animal experimental studies have demonstrated an association of arterial baroreflex impairment with the prognosis and mortality of cardiovascular diseases and diabetes. As a primary part of the arterial baroreflex arc, the pressure sensitivity of arterial baroreceptors is blunted and involved in arterial baroreflex dysfunction in cardiovascular diseases and diabetes. Changes in the arterial vascular walls, mechanosensitive ion channels, and voltage-gated ion channels contribute to the attenuation of arterial baroreceptor sensitivity. Some endogenous substances (such as angiotensin II and superoxide anion) can modulate these morphological and functional alterations through intracellular signaling pathways in impaired arterial baroreceptors. Arterial baroreceptors can be considered as a potential therapeutic target to improve the prognosis of patients with cardiovascular diseases and diabetes.

Indexed as

AnimalsBaroreflexBlood PressureCardiovascular DiseasesDiabetes MellitusHumansIon ChannelsPressoreceptorsIon ChannelsAngiotensin IIBaroreceptorBaroreflexCardiovascular diseaseDiabetesMechanosensitive ion channelsNuclear factor-kappa BSuperoxideVascular wallVoltage-gated ion channels

Identifiers

PMID30146675
PMCPMC6357267
OpenAlexW2889169994

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.