Evidence map›Paper›PMID 30146659›Full record

ArticleClinical oral investigations2019

Cytokine release kinetics of concentrated growth factors in different scaffolds.

Min Yu, Xiujing Wang, Yan Liu, Jing Qiao

Erratum issuedAbstract read
PubMed Publisher
In one paragraph

Article in Clinical oral investigations, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
5.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.

  1. Pooled it
  2. [Effect of concentrated growth factors in guided tissue regeneration for the treatment of mandibular molar furcation lesions].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2026
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  18. Applications of Metformin in Dentistry-A review.Journal of Taibah University Medical Sciences · 2023
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Min YuLaboratory of Biomimetic Nanomaterials, Department of Orthodontics, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Peking University School and Hospital of Stomatology, 22 Zhongguancun South Avenue, Haidian District, Beijing, 100081, China.
Xiujing WangDepartment of Orthodontics, The First Clinical Division, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Peking University School and Hospital of Stomatology, Beijing, 100034, China.
Yan LiuLaboratory of Biomimetic Nanomaterials, Department of Orthodontics, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Peking University School and Hospital of Stomatology, 22 Zhongguancun South Avenue, Haidian District, Beijing, 100081, China. orthoyan@bjmu.edu.cn.
Jing QiaoDepartment of Periodontology, The First Clinical Division, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Peking University School and Hospital of Stomatology, 37 Xishenku Avenue, Xicheng District, Beijing, 100034, China. donaldshushu@aliyun.com.ORCID http://orcid.org/0000-0002-5424-6984
Peking University · CNStomatology Hospital · CN

Funding

Beijing Municipal Natural Science Foundation 7152156National Natural Science Foundation of China 81571815National Natural Science Foundation of China 81600868New-star Plan of Science and Technology Z171100001117018
6 · The paper itself

Abstract

objectivesConcentrated growth factors (CGF) exhibit superior potential for periodontal tissue regeneration; however, little is known about the release pattern of CGF over time. This study was designed to investigate the in vitro release pattern of growth factors and cytokines from CGF in deproteinized bovine bone mineral (DBBM) and intrafibrillarly-mineralized collagen (IMC). MATERIALS AND

methodsCGF, CGF mixed with DBBM (CGF-DBBM), and CGF mixed with IMC (CGF-IMC) were cultured in vitro for 28 days and media supernatants were collected after 24 h, 72 h, and 7, 14, 21, and 28 days respectively. The factors investigated included platelet-derived growth factor-BB, transforming growth factor beta 1, vascular endothelial growth factor, insulin-like growth factor 1, basic fibroblast growth factor, C3a, and C5a.

resultsWe found that CGF-IMC released the highest total amount of cytokines compared to CGF and CGF-DBBM (p < 0.01). Growth factors were continuously released till 28 days. The release curves of most growth factors and cytokines included two peaks at 24 h and during 14 to 28 days. CGF-IMC released much more growth factors than CGF and CGF-DBBM during 14 to 28 days.

conclusionsWithin the limitation of the study, CGF-IMC offers advantages over CGF-DBBM and CGF for sustained release of growth factors and cytokines. CLINICAL RELEVANCE: This study provides strong evidence for clinical use of IMC used as a new carrier for CGF in periodontal regeneration. We need more studies to investigate the effect of sustained release of growth factors in tissue regeneration.

Indexed as

CollagenCytokinesTissue ScaffoldsVascular Endothelial Growth Factor AAnimalsBlood PlateletsCattleHumansKineticsCollagenCytokinesVascular Endothelial Growth Factor AConcentrated growth factorsCytokinesGrowth factorsPlatelet concentratesRelease kineticsScaffolds

Identifiers

PMID30146659
OpenAlexW2889387299

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.