ArticleCell metabolism2018
Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves mTOR Malonylation.
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Article in Cell metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 172 papers.
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172citing papers in PubMed
6.1field-weighted citation impact, top 2% of its field
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Who cites it
172 citing papers in PubMed, 278 citations in OpenAlex.
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- Ufmylation-Deficient DDRGK1 Ameliorates Obesity by Inhibiting FASN-Mediated Adipocyte Lipogenesis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
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- Commentary on "Targeting B7-H3 inhibition-induced activation of fatty acid synthesis boosts anti-B7-H3 immunotherapy in triple-negative breast cancer".Journal for immunotherapy of cancer · 2026Article
- Processes and therapeutic perspectives of acylation modifications of lysine and cysteine in tumors.Cell communication and signaling : CCS · 2026Review
- Dysregulation of the AMPK-SREBP1-FASN axis in MASLD: driving a vicious cycle of lipotoxicity and metabolic-immune crosstalk.Lipids in health and disease · 2026Review
- The UFL1-AKT positive feedback loop promotes breast cancer progression by enhancing lipid synthesis.Nature communications · 2026Article
- Orlistat: a comprehensive review of a lipase inhibitor from obesity management to emerging oncological applications.Frontiers in pharmacology · 2026Review
112 more citing papers are in PubMed but not listed here.
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Authors and funding
32 authors at 10 institutions in 5 countries.
Ulrike BruningLaboratory of Angiogenesis and Vascular Metabolism, VIB Center for Cancer Biology (CCB), VIB, 3000 Leuven, Belgium; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou 510060, Guangdong, P.R. China; Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology and Leuven Cancer Institute (LKI), KU Leuven, 3000 Leuven, Belgium.
Francisco Morales-RodriguezLaboratory of Angiogenesis and Vascular Metabolism, VIB Center for Cancer Biology (CCB), VIB, 3000 Leuven, Belgium; Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology and Leuven Cancer Institute (LKI), KU Leuven, 3000 Leuven, Belgium.
Joanna KaluckaLaboratory of Angiogenesis and Vascular Metabolism, VIB Center for Cancer Biology (CCB), VIB, 3000 Leuven, Belgium; Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology and Leuven Cancer Institute (LKI), KU Leuven, 3000 Leuven, Belgium.
Jermaine GoveiaLaboratory of Angiogenesis and Vascular Metabolism, VIB Center for Cancer Biology (CCB), VIB, 3000 Leuven, Belgium; Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology and Leuven Cancer Institute (LKI), KU Leuven, 3000 Leuven, Belgium.
Federico TavernaLaboratory of Angiogenesis and Vascular Metabolism, VIB Center for Cancer Biology (CCB), VIB, 3000 Leuven, Belgium; Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology and Leuven Cancer Institute (LKI), KU Leuven, 3000 Leuven, Belgium.
Karla C S QueirozLaboratory of Angiogenesis and Vascular Metabolism, VIB Center for Cancer Biology (CCB), VIB, 3000 Leuven, Belgium; Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology and Leuven Cancer Institute (LKI), KU Leuven, 3000 Leuven, Belgium.
Charlotte DuboisLaboratory of Angiogenesis and Vascular Metabolism, VIB Center for Cancer Biology (CCB), VIB, 3000 Leuven, Belgium; Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology and Leuven Cancer Institute (LKI), KU Leuven, 3000 Leuven, Belgium.
Anna Rita CantelmoLaboratory of Angiogenesis and Vascular Metabolism, VIB Center for Cancer Biology (CCB), VIB, 3000 Leuven, Belgium; Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology and Leuven Cancer Institute (LKI), KU Leuven, 3000 Leuven, Belgium.
Rongyuan ChenState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou 510060, Guangdong, P.R. China.
Stefan LorochLeibniz Institut für analytische Wissenschaften, ISAS, 44227 Dortmund, Germany.
Evy TimmermanVIB Center for Medical Biotechnology, 9000 Ghent, Belgium; Department of Biochemistry, Ghent University, 9000 Ghent, Belgium; VIB Proteomics Expertise Center, 9000 Ghent, Belgium.
Vanessa CaixetaLeibniz Institut für analytische Wissenschaften, ISAS, 44227 Dortmund, Germany.
Katarzyna BlochLaboratory of Lipid Metabolism and Cancer, Department of Oncology, KU Leuven, 3000 Leuven, Belgium.
Lena-Christin ConradiLaboratory of Angiogenesis and Vascular Metabolism, VIB Center for Cancer Biology (CCB), VIB, 3000 Leuven, Belgium; Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology and Leuven Cancer Institute (LKI), KU Leuven, 3000 Leuven, Belgium.
Lucas TrepsLaboratory of Angiogenesis and Vascular Metabolism, VIB Center for Cancer Biology (CCB), VIB, 3000 Leuven, Belgium; Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology and Leuven Cancer Institute (LKI), KU Leuven, 3000 Leuven, Belgium.
An StaesVIB Center for Medical Biotechnology, 9000 Ghent, Belgium; Department of Biochemistry, Ghent University, 9000 Ghent, Belgium; VIB Proteomics Expertise Center, 9000 Ghent, Belgium.
Kris GevaertVIB Center for Medical Biotechnology, 9000 Ghent, Belgium; Department of Biochemistry, Ghent University, 9000 Ghent, Belgium; VIB Proteomics Expertise Center, 9000 Ghent, Belgium.
Andrew TeeCardiff University, Cardiff CF14 4YS, UK.
Mieke DewerchinLaboratory of Angiogenesis and Vascular Metabolism, VIB Center for Cancer Biology (CCB), VIB, 3000 Leuven, Belgium; Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology and Leuven Cancer Institute (LKI), KU Leuven, 3000 Leuven, Belgium.
Clay F SemenkovichDivision of Endocrinology, Metabolism & Lipid Research, Washington University, St. Louis, MO 63110, USA.
Francis ImpensVIB Center for Medical Biotechnology, 9000 Ghent, Belgium; Department of Biochemistry, Ghent University, 9000 Ghent, Belgium; VIB Proteomics Expertise Center, 9000 Ghent, Belgium.
Birgit SchillingBuck Institute for Research on Aging, Novato, CA 94945, USA.
Eric VerdinBuck Institute for Research on Aging, Novato, CA 94945, USA.
Johannes V SwinnenLaboratory of Lipid Metabolism and Cancer, Department of Oncology, KU Leuven, 3000 Leuven, Belgium.
Jordan L MeierNational Cancer Institute, Frederick, MD 21702, USA.
Rhushikesh A KulkarniNational Cancer Institute, Frederick, MD 21702, USA.
Albert SickmannLeibniz Institut für analytische Wissenschaften, ISAS, 44227 Dortmund, Germany.
Bart GhesquièreMetabolomics Core Facility, Department of Oncology, KU Leuven, 3000 Leuven, Belgium; Metabolomics Core Facility, VIB Center for Cancer Biology (CCB), VIB, 3000 Leuven, Belgium.
Luc SchoonjansLaboratory of Angiogenesis and Vascular Metabolism, VIB Center for Cancer Biology (CCB), VIB, 3000 Leuven, Belgium; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou 510060, Guangdong, P.R. China; Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology and Leuven Cancer Institute (LKI), KU Leuven, 3000 Leuven, Belgium.
Xuri LiState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou 510060, Guangdong, P.R. China. Electronic address: lixr6@mail.sysu.edu.cn.
Massimiliano MazzoneLaboratory of Tumor Inflammation and Angiogenesis, VIB Center for Cancer Biology (CCB), VIB, 3000 Leuven, Belgium; Laboratory of Tumor Inflammation and Angiogenesis, Department of Oncology, KU Leuven, 3000 Leuven, Belgium.
Peter CarmelietLaboratory of Angiogenesis and Vascular Metabolism, VIB Center for Cancer Biology (CCB), VIB, 3000 Leuven, Belgium; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou 510060, Guangdong, P.R. China; Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology and Leuven Cancer Institute (LKI), KU Leuven, 3000 Leuven, Belgium. Electronic address: peter.carmeliet@kuleuven.vib.be.
VIB-KU Leuven Center for Cancer Biology · BEKU Leuven · BEGhent University · BELeibniz Institute for Analytical Sciences - ISAS · DESun Yat-sen University · CNBuck Institute for Research on Aging · USNational Cancer Institute · USCardiff University · GBVIB-UGent Center for Medical Biotechnology · BEWashington University in St. Louis · US
Funding
Targeting Cancer Through Modifications and MetabolismZIABC011488 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI MEIER, JORDAN L · 2013 to 2025
$21.3MIntramural NIH HHS ZIA BC011488
Abstract
The role of fatty acid synthesis in endothelial cells (ECs) remains incompletely characterized. We report that fatty acid synthase knockdown (FASN
Indexed as
Acetyl-CoA CarboxylaseAnimalsCell Line, TumorCell ProliferationFatty Acid Synthase, Type IHumansHuman Umbilical Vein Endothelial CellsMalonyl Coenzyme AMechanistic Target of Rapamycin Complex 1MiceMice, Inbred C57BLMice, KnockoutOrlistatProtein Processing, Post-TranslationalRetinal NeovascularizationTOR Serine-Threonine KinasesACACA protein, humanAcetyl-CoA CarboxylaseFASN protein, humanFatty Acid Synthase, Type IMalonyl Coenzyme AMechanistic Target of Rapamycin Complex 1MTOR protein, humanOrlistatTOR Serine-Threonine Kinasesangiogenesisendothelial cellfatty acid synthaselipidsmalonyl-CoAmetabolismmTORmTORC1post-translational modificationsprotein malonylation
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