Evidence map›Paper›PMID 30146485›Full record

ArticleCell metabolism2018

Nucleus of the Solitary Tract Serotonin 5-HT

Giuseppe D'Agostino, David Lyons, Claudia Cristiano, Miriam Lettieri, Cristian Olarte-Sanchez, Luke K Burke, Megan Greenwald-Yarnell, Celine Cansell, Barbora Doslikova, Teodora Georgescu and 4 more

Open access · hybridAbstract read
In one paragraph

Article in Cell metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.

0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed
6.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

85 citing papers in PubMed, 143 citations in OpenAlex.

  1. Defining Predictors of Weight Loss Response to Lorcaserin.The Journal of clinical endocrinology and metabolism · 2023
    Trial
  2. Article
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  4. Review
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  8. Article
  9. The Genetic Blueprint of Obesity: From Pathogenesis to Novel Therapies.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025
    Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. G proteins of the GScience advances · 2025
    Article
  15. Article
  16. Article
  17. Review
  18. Frontiers in behavioral neuroscience · 2025
    Review
  19. Nutrients · 2024
    Article
  20. Article

25 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Giuseppe D'AgostinoRowett Institute, University of Aberdeen, Aberdeen, UK; Department of Pharmacology, University of Cambridge, Cambridge, UK. Electronic address: giuseppe.dagostino@abdn.ac.uk.
David LyonsRowett Institute, University of Aberdeen, Aberdeen, UK.
Claudia CristianoRowett Institute, University of Aberdeen, Aberdeen, UK.
Miriam LettieriRowett Institute, University of Aberdeen, Aberdeen, UK.
Cristian Olarte-SanchezRowett Institute, University of Aberdeen, Aberdeen, UK.
Luke K BurkeDepartment of Pharmacology, University of Cambridge, Cambridge, UK.
Megan Greenwald-YarnellDivision of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Celine CansellRowett Institute, University of Aberdeen, Aberdeen, UK.
Barbora DoslikovaDepartment of Pharmacology, University of Cambridge, Cambridge, UK.
Teodora GeorgescuRowett Institute, University of Aberdeen, Aberdeen, UK.
Pablo Blanco Martinez de MorentinRowett Institute, University of Aberdeen, Aberdeen, UK.
Martin G MyersDivision of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Justin J RochfordRowett Institute, University of Aberdeen, Aberdeen, UK.
Lora K HeislerRowett Institute, University of Aberdeen, Aberdeen, UK; Department of Pharmacology, University of Cambridge, Cambridge, UK. Electronic address: lora.heisler@abdn.ac.uk.
University of Aberdeen · GBUniversity of Cambridge · GBUniversity of Michigan–Ann Arbor · US

Funding

Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3M
University of Michigan Center for Gastrointestinal ResearchP30DK034933 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI OWYANG, CHUNG · 1986 to 2021
$22.5M
MOLECULAR DETERMINANTS OF LEPTIN RECEPTOR/JAK2 SIGNALINGR01DK056731 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MYERS, MARTIN G · 1999 to 2025
$6.0M
Molecular Mechanisms of Leptin Receptor/Jak2 ActionR37DK056731 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MYERS, MARTIN G · 2008 to 2017
$3.5M
Biotechnology and Biological Sciences Research Council BB/K001418/1Biotechnology and Biological Sciences Research Council BB/K017772/1Biotechnology and Biological Sciences Research Council BB/N017838/1Medical Research Council MC/PC/15077Medical Research Council MC_PC_15077Medical Research Council MR/L002620/1Medical Research Council MR/P009824/1NIDDK NIH HHS P30 DK020572NIDDK NIH HHS P30 DK034933NIDDK NIH HHS R01 DK056731NIDDK NIH HHS R37 DK056731Wellcome TrustWellcome Trust 105625/Z/14/ZWellcome Trust WT098012
6 · The paper itself

Abstract

To meet the challenge to human health posed by obesity, a better understanding of the regulation of feeding is essential. Medications targeting 5-hydroxytryptamine (5-HT; serotonin) 2C receptors (htr2c; 5-HT

Indexed as

Analysis of VarianceAnimalsAppetite DepressantsAppetite RegulationArcuate Nucleus of HypothalamusBenzazepinesCell Line, TumorEatingFeeding BehaviorMaleMiceMice, KnockoutNeuronsObesityReceptor, Serotonin, 5-HT2CSerotonin 5-HT2 Receptor AgonistsAppetite DepressantsBenzazepineslorcaserinReceptor, Serotonin, 5-HT2CSerotonin 5-HT2 Receptor Agonists5-HT(2C)Rfood intakelorcaserinnucleus of the solitary tractobesityserotonin

Identifiers

PMID30146485
PMCPMC6371983
OpenAlexW2888031074

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.