ArticleCancer cell2018
Identification of Therapeutic Targets in Rhabdomyosarcoma through Integrated Genomic, Epigenomic, and Proteomic Analyses.
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Article in Cancer cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers, 1 of them a synthesis that pooled it.
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107citing papers in PubMed, 1 pooled it
11.9field-weighted citation impact, top 1% of its field
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Who cites it
107 citing papers in PubMed, 1 synthesis or guideline pooled it, 164 citations in OpenAlex.
- Relapsed rhabdomyosarcoma: treatment recommendations from the European pediatric soft tissue sarcoma study group (EpSSG).British journal of cancer · 2025Guideline
- Palbociclib in Solid Tumor Patients With Genomic Alterations in the cyclinD-cdk4/6-INK4a-Rb Pathway: Results From National Cancer Institute-Children's Oncology Group Pediatric Molecular Analysis for Therapy Choice Trial Arm I (APEC1621I).JCO precision oncology · 2024Trial
- Trial
- High-Risk Rhabdomyosarcomas Feature a Convergent Cell State.Cancer research · 2026Article
- Epigenetic modifications in cancer drug resistance: molecular mechanisms and therapeutic interventions.Molecular biomedicine · 2026Review
- Targeting the p53 pathway to treat atypical teratoid rhabdoid tumors.Neuro-oncology pediatrics · 2026Article
- The PIK3CA/AKT pathway drives therapy resistance in rhabdomyosarcoma.Nature communications · 2025Article
- Transdifferentiation of endothelial progenitor cells into rhabdomyosarcoma defined by hedgehog signaling competence.Cell reports · 2025Article
- MyoD is essential in rhabdomyosarcoma by promoting survival through differentiation and CYLD.iScience · 2025Article
- Article
- Article
- Multi-omics analyses reveal biological and clinical insights in recurrent stage I non-small cell lung cancer.Nature communications · 2025Article
- ASAP1 and ARF1 Regulate Myogenic Differentiation in Rhabdomyosarcoma by Modulating TAZ Activity.Molecular cancer research : MCR · 2025Article
- Characterization of a pleomorphic rhabdomyosarcoma cell line.Scientific reports · 2025Article
- A computational tool to infer enzyme activity using post-translational modification profiling data.Communications biology · 2025Article
- Case Report: Relapsed alveolar rhabdomyosarcoma treated with abemaciclib, temozolomide, and irinotecan in the JPCS study.Frontiers in oncology · 2025Article
- Disrupting resistance: novel therapeutic approaches to combat multidrug resistance in fusion-negative rhabdomyosarcoma.Cancer drug resistance (Alhambra, Calif.) · 2025Review
- Lysine p-nitroanilide impairs cellular energetics and potentiates statin-induced cytotoxicity in RD rhabdomyosarcoma cells.PloS one · 2025Article
- SJPedPanel: A Pan-Cancer Gene Panel for Childhood Malignancies to Enhance Cancer Monitoring and Early Detection.Clinical cancer research : an official journal of the American Association for Cancer Research · 2024Article
- Pediatric cancer-pathology and microenvironment influence: a perspective into osteosarcoma and non-osteogenic mesenchymal malignant neoplasms.Discover oncology · 2024Review
47 more citing papers are in PubMed but not listed here.
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Authors and funding
39 authors at 4 institutions in 1 country.
Elizabeth StewartDepartment of Developmental Neurobiology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, MS 323, Memphis, TN 38105-3678, USA; Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Justina McEvoyDepartments of Molecular and Cellular Biology and Pediatrics, BIO5 Institute, University of Arizona, Tucson, AZ 85721, USA.
Hong WangDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Integrated Biomedical Sciences, University of Tennessee Health Science Center, Memphis, TN 38105, USA.
Xiang ChenDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Victoria HonnellDepartment of Developmental Neurobiology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, MS 323, Memphis, TN 38105-3678, USA; Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Monica OcarzDepartment of Developmental Neurobiology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, MS 323, Memphis, TN 38105-3678, USA.
Brittney GordonDepartment of Developmental Neurobiology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, MS 323, Memphis, TN 38105-3678, USA.
Jason DapperDepartment of Developmental Neurobiology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, MS 323, Memphis, TN 38105-3678, USA; Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Kaley BlankenshipDepartment of Oncology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Yanling YangDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Yuxin LiDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Proteomics Shared Resource, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Timothy I ShawDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Proteomics Shared Resource, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Ji-Hoon ChoProteomics Shared Resource, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Xusheng WangProteomics Shared Resource, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Beisi XuDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Pankaj GuptaDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Yiping FanDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Yu LiuDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Michael RuschDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Lyra GriffithsDepartment of Developmental Neurobiology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, MS 323, Memphis, TN 38105-3678, USA.
Jongrye JeonDepartment of Developmental Neurobiology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, MS 323, Memphis, TN 38105-3678, USA.
Burgess B FreemanPreclinical Pharmacokinetics Shared Resource, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Michael R ClayDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Alberto PappoDepartment of Oncology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
John EastonDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Sheila ShurtleffDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Anang ShelatDepartment of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Xin ZhouDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Kristy BoggsDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Heather MulderDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Donald YergeauDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Armita BahramiDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Elaine R MardisThe McDonnell Genome Institute, Washington University, St. Louis, MO 63108, USA; Department of Genetics, Washington University, St. Louis, MO 63108, USA; Department of Medicine, Washington University, St. Louis, MO 63108, USA.
Richard K WilsonThe McDonnell Genome Institute, Washington University, St. Louis, MO 63108, USA; Department of Genetics, Washington University, St. Louis, MO 63108, USA; Siteman Cancer Center, Washington University School of Medicine in St. Louis, St. Louis, MO 63108, USA.
Jinghui ZhangDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Junmin PengDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
James R DowningDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Michael A DyerDepartment of Developmental Neurobiology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, MS 323, Memphis, TN 38105-3678, USA; Department of Ophthalmology, University of Tennessee Health Science Center, Memphis, TN 38105, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA. Electronic address: michael.dyer@stjude.org.
St. Jude Children's Research Hospital – Washington University Pediatric Cancer Genome Project
St. Jude Children's Research Hospital · USJames S. McDonnell Foundation · USUniversity of Tennessee Health Science Center · USUniversity of Arizona · US
Funding
Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 1985 to 2026
$166.9MProliferation Control in the Retina: The Rb FamilyR01EY014867 · NEI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI DYER, MICHAEL A · 2003 to 2012
$4.5MProliferation and Differentiation of Retinal Stem CellsR01EY018599 · NEI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI DYER, MICHAEL A · 2008 to 2011
$2.5MNovel Therapeutic Approaches for the Treatment of RhabdomyosarcomaR01CA219686 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI DYER, MICHAEL A · 2017 to 2021
$2.0MRNA splicing dysfunction in Alzheimer's diseaseR01AG047928 · NIA · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI PENG, JUNMIN · 2015 to 2019
$1.8MMolecular Targeted Therapy for RetinoblastomaR01CA168875 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI DYER, MICHAEL A · 2012 to 2016
$1.8MHoward Hughes Medical InstituteNCI NIH HHS P30 CA021765NCI NIH HHS R01 CA168875NCI NIH HHS R01 CA219686NEI NIH HHS R01 EY014867NEI NIH HHS R01 EY018599NIA NIH HHS R01 AG047928
Abstract
Personalized cancer therapy targeting somatic mutations in patient tumors is increasingly being incorporated into practice. Other therapeutic vulnerabilities resulting from changes in gene expression due to tumor specific epigenetic perturbations are progressively being recognized. These genomic and epigenomic changes are ultimately manifest in the tumor proteome and phosphoproteome. We integrated transcriptomic, epigenomic, and proteomic/phosphoproteomic data to elucidate the cellular origins and therapeutic vulnerabilities of rhabdomyosarcoma (RMS). We discovered that alveolar RMS occurs further along the developmental program than embryonal RMS. We also identified deregulation of the RAS/MEK/ERK/CDK4/6, G
Indexed as
AnimalsAntineoplastic AgentsBiomarkers, TumorCell Cycle ProteinsCell Line, TumorChildEpigenomicsFemaleG2 Phase Cell Cycle CheckpointsGene Expression ProfilingGene Expression Regulation, NeoplasticGenomicsHumansMaleMiceMolecular Targeted TherapyAntineoplastic AgentsBiomarkers, TumorCell Cycle ProteinsNuclear ProteinsProtein-Tyrosine KinasesWEE1 protein, humanepigeneticsmolecular targeted therapypediatric cancerpreclinical testingproteomicsrhabdomyosarcoma
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.