ArticleNeuron2018
An Afferent Neuropeptide System Transmits Mechanosensory Signals Triggering Sensitization and Arousal in C. elegans.
Article in Neuron, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 71 citations in OpenAlex.
- DeorphaNN: Virtual screening of GPCR peptide agonists using AlphaFold-predicted active-state complexes and deep learning embeddings.Molecular cell · 2026Article
- Mechanosensory encoding of surface mechanics optimizes locomotion.Nature communications · 2026Article
- Habituation and sensitization learning in adult solitary ascidians.Scientific reports · 2026Article
- The FMRFamide-like peptide FLP-11 regulates the production and secretion of the TGF-β-like protein DAF-7 during Caenorhabditis elegans larval development.Scientific reports · 2026Article
- Neuropeptides Are Involved in Elicited Reversal Speed Plasticity inmicroPublication biology · 2026Article
- Identification of molecular nociceptors in Octopus vulgaris through functional characterisation in Caenorhabditis elegans.Biology open · 2026Article
- Article
- Neuropeptides Involved in Elicited Reversal Speed Plasticity inbioRxiv : the preprint server for biology · 2025Article
- Dopaminergic Modulation of Short-Term Associative Memory in Caenorhabditis elegans.Journal of neurochemistry · 2025Article
- Mapping and decoding neuropeptide signaling networks in nervous system function.Current opinion in neurobiology · 2025Review
- Sources of behavioral variability in C. elegans: Sex differences, individuality, and internal states.Current opinion in neurobiology · 2025Review
- Neuropeptide signaling network of Caenorhabditis elegans: from structure to behavior.Genetics · 2024Review
- Robotic microinjection enables large-scale transgenic studies of Caenorhabditis elegans.Nature communications · 2024Article
- Advanced Neural Functional Imaging inMicromachines · 2024Review
- Behavioral adjustment of C. elegans to mechanosensory loss requires intact mechanosensory neurons.PLoS biology · 2024Article
- Dynamic temperature control in microfluidics for in vivo imaging of cold-sensing in C. elegans.Biophysical journal · 2024Article
- Evolutionary conserved peptide and glycoprotein hormone-like neuroendocrine systems in C. elegans.Molecular and cellular endocrinology · 2024Article
- High-Resolution Imaging and Morphological Phenotyping ofResearch (Washington, D.C.) · 2024Article
- Neural mechanisms of dopamine function in learning and memory inNeuronal signaling · 2024Review
- The neuropeptidergic connectome of C. elegans.Neuron · 2023Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 5 countries.
Funding
Abstract
Sensitization is a simple form of behavioral plasticity by which an initial stimulus, often signaling danger, leads to increased responsiveness to subsequent stimuli. Cross-modal sensitization is an important feature of arousal in many organisms, yet its molecular and neural mechanisms are incompletely understood. Here we show that in C. elegans, aversive mechanical stimuli lead to both enhanced locomotor activity and sensitization of aversive chemosensory pathways. Both locomotor arousal and cross-modal sensitization depend on the release of FLP-20 neuropeptides from primary mechanosensory neurons and on their receptor FRPR-3. Surprisingly, the critical site of action of FRPR-3 for both sensory and locomotor arousal is RID, a single neuroendocrine cell specialized for the release of neuropeptides that responds to mechanical stimuli in a FLP-20-dependent manner. Thus, FLP-20 peptides function as an afferent arousal signal that conveys mechanosensory information to central neurons that modulate arousal and other behavioral states.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.