ArticleCell2018
TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging.
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Article in Cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 279 papers.
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279citing papers in PubMed
16.5field-weighted citation impact, top 1% of its field
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Who cites it
279 citing papers in PubMed, 448 citations in OpenAlex.
- Transglutaminase 2 regulates innate immunity: mechanisms and therapeutic implications.Oncoimmunology · 2026Review
- Necroptosis and the RIPK1-RIPK3-MLKL pathway in chronic kidney disease: mechanisms, crosstalk, and therapeutic opportunities.Renal failure · 2026Review
- Death domain-mediated higher-order oligomerization of RIPK1 drives TNF-induced signaling.Cell death and differentiation · 2026Article
- Mechanisms, regulation and clinical relevance of necroptosis.Nature reviews. Molecular cell biology · 2026Review
- HERC4-mediated ubiquitination licenses RIPK1 to initiate TNF-induced cell death.Nature structural & molecular biology · 2026Article
- Convergent TBK1 loss of function drives gasdermin E dependent pyroptosis and motor neuron degeneration across ALS genotypes.Cell death and differentiation · 2026Article
- Reduced endothelial TAK1 impairs vascular integrity in cerebral small vessel diseaseStroke and vascular neurology · 2026Article
- Bridging the gap: neuroinflammation and the dawn of precision medicine in amyotrophic lateral sclerosis.Translational neurodegeneration · 2026Review
- LXR Pathway Activation by T0901317: A Novel Potential Experimental Strategy for ALS-Related Cognitive and Motor Impairments via Suppression of Necroptosis-associated RIPK1/RIPK3/MLKL Markers.Molecular neurobiology · 2026Article
- Oncogenic EGFR rewires STING-TBK1 signalosomes to license DNA damage tolerance in NSCLC.The EMBO journal · 2026Article
- AGGF1 delays endothelial cellular senescence through the TGFB3-TAK1-AMPK signaling axis.Biogerontology · 2026Article
- PANoptosis in the pathogenesis of myelodysplastic syndromes.Molecular oncology · 2026Review
- Species-specific regulation of necroptosis by STK38-dependent RIPK1 phosphorylation.Cell death and differentiation · 2026Article
- BioMedGraphica: an all-in-one platform for joint textual biomedical prior knowledge and numeric graph generation.Bioinformatics (Oxford, England) · 2026Article
- Metastable Protein-Protein Interactions as a Design Principle for PROTACs: Insights from the RIPK1-VHL System.JACS Au · 2026Article
- APOE-stratified Proteomic and Metabolomic Analysis Reveals Mitochondrial Dysfunction Inflammation and Lipid Dysregulation in Alzheimer's Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- CD8Nature communications · 2026Article
- Cytosolic nucleic acid sensing triggers type I interferon activation via the Hippo kinase LATS1.The Journal of biological chemistry · 2026Article
- Traumatic Brain Injury and Axonal Damage in the Pathogenesis of Frontotemporal Dementia: A Narrative Review.Cureus · 2026Review
- Cancer neuroscience: signaling pathways and new therapeutic strategies for cancer.Signal transduction and targeted therapy · 2026Review
219 more citing papers are in PubMed but not listed here.
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Authors and funding
20 authors at 4 institutions in 2 countries.
Daichao XuDepartment of Cell Biology, Harvard Medical School, 240 Longwood Ave., Boston, MA 02115, USA.
Taijie JinInterdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 26 Qiuyue Rd., Pudong, 201210 Shanghai, China; University of Chinese Academy of Sciences, 100049 Beijing, China.
Hong ZhuDepartment of Cell Biology, Harvard Medical School, 240 Longwood Ave., Boston, MA 02115, USA.
Hongbo ChenDepartment of Cell Biology, Harvard Medical School, 240 Longwood Ave., Boston, MA 02115, USA.
Dimitry OfengeimDepartment of Cell Biology, Harvard Medical School, 240 Longwood Ave., Boston, MA 02115, USA.
Chengyu ZouDepartment of Cell Biology, Harvard Medical School, 240 Longwood Ave., Boston, MA 02115, USA.
Lauren MifflinDepartment of Cell Biology, Harvard Medical School, 240 Longwood Ave., Boston, MA 02115, USA.
Lifeng PanShanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Rd., 200032 Shanghai, China.
Palak AminDepartment of Cell Biology, Harvard Medical School, 240 Longwood Ave., Boston, MA 02115, USA.
Wanjin LiDepartment of Cell Biology, Harvard Medical School, 240 Longwood Ave., Boston, MA 02115, USA.
Bing ShanInterdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 26 Qiuyue Rd., Pudong, 201210 Shanghai, China.
Masanori Gomi NaitoDepartment of Cell Biology, Harvard Medical School, 240 Longwood Ave., Boston, MA 02115, USA.
Huyan MengInterdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 26 Qiuyue Rd., Pudong, 201210 Shanghai, China; University of Chinese Academy of Sciences, 100049 Beijing, China.
Ying LiInterdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 26 Qiuyue Rd., Pudong, 201210 Shanghai, China.
Heling PanInterdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 26 Qiuyue Rd., Pudong, 201210 Shanghai, China.
Liviu AronDepartment of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Xian AdiconisBroad Institute, Cambridge, MA 02142, USA.
Joshua Z LevinBroad Institute, Cambridge, MA 02142, USA.
Bruce A YanknerDepartment of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Junying YuanDepartment of Cell Biology, Harvard Medical School, 240 Longwood Ave., Boston, MA 02115, USA; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 26 Qiuyue Rd., Pudong, 201210 Shanghai, China. Electronic address: jyuan@hms.harvard.edu.
Harvard University · USShanghai Institute of Organic Chemistry · CNBroad Institute · USChinese Academy of Sciences · CN
Funding
Targeting a Novel Regulator of Brain Aging and Alzheimer's Disease (ADMINISTRATIVE SUPPLEMENT- SAGE)R01AG046174 · NIA · HARVARD MEDICAL SCHOOL · PI TSAI, LI-HUEI, YANKNER, BRUCE A · 2014 to 2018
$4.9MExploring a Novel Paradigm of Schizophrenia and Bipolar DisorderR01MH113279 · NIMH · HARVARD MEDICAL SCHOOL · PI CHURCH, GEORGE M, YANKNER, BRUCE A · 2016 to 2020
$4.7MSingle cell RNA-seq analyses of age-related changes in glial cells and in ADRF1AG055521 · NIA · HARVARD MEDICAL SCHOOL · PI YUAN, JUNYING · 2017 to 2017
$2.9MInvestigating the neuroinflammatory role of RIP1 kinaseR01AG047231 · NIA · HARVARD MEDICAL SCHOOL · PI YUAN, JUNYING · 2014 to 2018
$2.2MInvestigating the mechanism of TNFalpha mediated cell death in oligodendrocytesR01NS082257 · NINDS · HARVARD MEDICAL SCHOOL · PI YUAN, JUNYING · 2013 to 2017
$1.9MNIA NIH HHS R01 AG046174NIA NIH HHS R01 AG047231NIA NIH HHS RF1 AG055521NIMH NIH HHS R01 MH113279NINDS NIH HHS R01 NS082257
Abstract
Aging is a major risk factor for both genetic and sporadic neurodegenerative disorders. However, it is unclear how aging interacts with genetic predispositions to promote neurodegeneration. Here, we investigate how partial loss of function of TBK1, a major genetic cause for amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) comorbidity, leads to age-dependent neurodegeneration. We show that TBK1 is an endogenous inhibitor of RIPK1 and the embryonic lethality of Tbk1
Indexed as
ApoptosisAdultAgedAgingAnimalsAxonsBehavior, AnimalBrainCells, CulturedHumansI-kappa B KinaseMiceMice, KnockoutMicrogliaPhosphorylationProtein Serine-Threonine KinasesI-kappa B KinaseProtein Serine-Threonine KinasesReceptor-Interacting Protein Serine-Threonine KinasesRipk1 protein, mouseStaurosporineTbk1 protein, mouseTumor Necrosis Factor-alphaALScaspaseFTDnecroptosisRIPK1RIPK1-dependent apoptosisTAK1TBK1
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.