ArticleCurrent biology : CB2018
The Genomic Basis of Color Pattern Polymorphism in the Harlequin Ladybird.
Article in Current biology : CB, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed.
- Genomic Predictors of Diapause Polymorphism in the Bark Beetle Ips typographus With Implications for Voltinism Potential and Outbreak Dynamics.Molecular ecology · 2026Article
- Sex-Specific doublesex Regulation Targeting the Color-Patterning Gene h Underlies the Evolution of Wing Sexual Dimorphism in the Harlequin Ladybug Harmonia axyridis.Evolution & development · 2026Article
- Adaptation ofEvolutionary applications · 2025Article
- Molecular evolution of dietary shifts in ladybird beetles (Coleoptera: Coccinellidae): from fungivory to carnivory and herbivory.BMC biology · 2025Article
- Article
- Local genetic adaptation to habitat in wild chimpanzees.Science (New York, N.Y.) · 2025Article
- Egg Microinjection for the Ladybird BeetleBio-protocol · 2024Article
- Local genetic adaptation to habitat in wild chimpanzees.bioRxiv : the preprint server for biology · 2024Article
- PhyloAln: A Convenient Reference-Based Tool to Align Sequences and High-Throughput Reads for Phylogeny and Evolution in the Omic Era.Molecular biology and evolution · 2024Article
- Dominance reversals: the resolution of genetic conflict and maintenance of genetic variation.Proceedings. Biological sciences · 2024Review
- Whole-Genome Resequencing-Based Qualitative Trait Locus Mapping CorrelatedAnimals : an open access journal from MDPI · 2024Article
- Transposable Element Insertions Are Associated with Batesian Mimicry in the Pantropical Butterfly Hypolimnas misippus.Molecular biology and evolution · 2024Article
- Chromosome-level genome assembly of the giant ladybug Megalocaria dilatata.Scientific data · 2024Article
- Contrasting Evolutionary Patterns Between Sexual and Asexual Lineages in a Genomic Region Linked to Reproductive Mode Variation in the pea aphid.Genome biology and evolution · 2023Article
- Spatially differential regulation of ATF2 phosphorylation contributes to warning coloration of gregarious locusts.Science advances · 2023Article
- LPF: a framework for exploring the wing color pattern formation of ladybird beetles in Python.Bioinformatics (Oxford, England) · 2023Article
- Global patterns of genomic and phenotypic variation in the invasive harlequin ladybird.BMC biology · 2023Article
- A chromosome-level genome assembly of the Henosepilachna vigintioctomaculata provides insights into the evolution of ladybird beetles.DNA research : an international journal for rapid publication of reports on genes and genomes · 2023Article
- Shell color polymorphism in marine gastropods.Evolutionary applications · 2023Review
- The genome sequence of the orange ladybird,Wellcome open research · 2023Article
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Authors and funding
21 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many animal species comprise discrete phenotypic forms. A common example in natural populations of insects is the occurrence of different color patterns, which has motivated a rich body of ecological and genetic research [1-6]. The occurrence of dark, i.e., melanic, forms displaying discrete color patterns is found across multiple taxa, but the underlying genomic basis remains poorly characterized. In numerous ladybird species (Coccinellidae), the spatial arrangement of black and red patches on adult elytra varies wildly within species, forming strikingly different complex color patterns [7, 8]. In the harlequin ladybird, Harmonia axyridis, more than 200 distinct color forms have been described, which classic genetic studies suggest result from allelic variation at a single, unknown, locus [9, 10]. Here, we combined whole-genome sequencing, population-based genome-wide association studies, gene expression, and functional analyses to establish that the transcription factor Pannier controls melanic pattern polymorphism in H. axyridis. We show that pannier is necessary for the formation of melanic elements on the elytra. Allelic variation in pannier leads to protein expression in distinct domains on the elytra and thus determines the distinct color patterns in H. axyridis. Recombination between pannier alleles may be reduced by a highly divergent sequence of ∼170 kb in the cis-regulatory regions of pannier, with a 50 kb inversion between color forms. This most likely helps maintain the distinct alleles found in natural populations. Thus, we propose that highly variable discrete color forms can arise in natural populations through cis-regulatory allelic variation of a single gene.
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