ArticleThe Journal of pediatrics2018
Early Life Adversity with Height Stunting Is Associated with Cardiometabolic Risk in Adolescents Independent of Body Mass Index.
Article in The Journal of pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- Early-life adversity before age 5 is associated with reduced cardiometabolic health characterized by increased arterial stiffness and inflammation in adolescence.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2026Article
- The Impact of Early-Life Growth on Long-Term Cardiometabolic and Neurocognitive Outcomes in High-Income Countries: A Neglected Public Health Problem.Nutrition reviews · 2026Review
- Associations of height-for-age and BMI-for-ageFrontiers in nutrition · 2026Article
- Nocturnal Autonomic Nervous System and Jaw Muscle Activities and Ramus Height in Children.Orthodontics & craniofacial research · 2025Observational
- Early life adversity has sex-dependent effects on survival across the lifespan in rhesus macaques.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- Female adolescents' early life stress and body mass index: Differential effects of anger and anxiety in response to rejection.Journal of adolescence · 2024Article
- Effects of Perinatal Antibiotic Exposure and Neonatal Gut Microbiota.Antibiotics (Basel, Switzerland) · 2023Review
- Does rapid rebound height growth come at a neurocognitive cost for previously institutionalized youth?Journal of child psychology and psychiatry, and allied disciplines · 2022Article
- Change of pace: How developmental tempo varies to accommodate failed provision of early needs.Neuroscience and biobehavioral reviews · 2021Review
- What was learned from studying the effects of early institutional deprivation.Pharmacology, biochemistry, and behavior · 2021Review
- Integrating anthropometric and cardiometabolic health methods in stress, early experiences, and development (SEED) science.Developmental psychobiology · 2021Review
- Neonatal antibiotic exposure impairs child growth during the first six years of life by perturbing intestinal microbial colonization.Nature communications · 2021Article
- Article
- Examining the Influence of Early Life Stress on Serum Lipid Profiles and Cognitive Functioning in Depressed Patients.Frontiers in psychology · 2019Article
- Dual X-Ray absorptiometry leg length in youth.Journal of clinical densitometry : the official journal of the International Society for Clinical DensitometryArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo evaluate cardiovascular and metabolic function in youths adopted internationally from orphanages/institutions (postinstitutionalized) who were height-stunted at adoption. STUDY
designA total of 30 postinstitutionalized youths (age, 9-18 years; body mass index [BMI] percentile, 7.2-90.4) who were height-stunted at adoption were compared with age- and BMI percentile-matched youths (n = 90). Measurements included total body fat and visceral adipose tissue (dual radiograph absorptiometry), arterial stiffness (augmentation index and pulse wave velocity), cardiac autonomic function (heart rate variability), blood pressure, and fasting lipid, glucose, and insulin levels. Linear regression analyses were computed controlling for parent education, age, trunk tissue fat, height-for-age, sex, and race.
resultsCompared with controls of the same age, sex, and BMI, the postinstitutionalized children had higher systolic blood pressure (P = .018), augmentation index (P= .033), total cholesterol (P= .047), low-density lipoprotein cholesterol (P= .03), triglycerides (P= .048), insulin (P= .005), and HOMA-IR (P= .01) values. The postinstitutionalized children had a lower low-frequency to high-frequency ratio (P = .008), indicating lower sympathetic tone, as well as a lower total lean mass (P = .016), a lower gynoid lean mass (P = .039), and a higher proportion of trunk tissue fat (P = .017). The postinstitutionalized and control children did not differ in any other body composition measures.
conclusionsEarly life stress, as represented by height-stunted growth in institutional care, may be associated with early pathways to cardiovascular and metabolic risk in youths even after moving into well-resourced homes early in life and in the absence of increased adiposity. These findings suggest that postinstitutionalized youths with a history of height stunting may need to be closely monitored for emergent cardiometabolic risk factors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.