ReviewInternational review of neurobiology2018
Optimizing Placebo and Minimizing Nocebo to Reduce Pain, Catastrophizing, and Opioid Use: A Review of the Science and an Evidence-Informed Clinical Toolkit.
Review in International review of neurobiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Addressing Opioid Use Disorder With an External Multimodal Neuromodulation Device: Development and Clinical Evaluation of DuoTherm for Opioid-Sparing Pain Relief in Acute and Chronic Low Back Pain
Addressing Pain and Disability From Low Back Pain With an External Multimodal Neuromodulation Device
Addressing Feasibility of the DuoTherm in Acute and Chronic Low Back Pain
Who cites it
34 citing papers in PubMed, 62 citations in OpenAlex.
- Top-down control of the descending pain modulatory system drives multimodal placebo analgesia.Neuron · 2026Article
- Language-games in live mindfulness-based stress reduction: a philosophy of language analysis of participant-trainer dialogue.Frontiers in psychology · 2026Article
- Differential Predictive Capabilities of Cognitive Performance on Psychological Pain Variables in Chronic Low Back Pain.Pain research & management · 2026Article
- The High-Risk Model of Threat Perception Modulates Learning of Placebo and Nocebo Effects and Functional Somatic Disorders.Brain sciences · 2025Review
- An update on non-pharmacological interventions for pain relief.Cell reports. Medicine · 2025Review
- Novel multimodal mechanical stimulation is superior to TENS to treat and prevent chronic low back pain: a randomized controlled trial.Frontiers in pain research (Lausanne, Switzerland) · 2025Article
- Preventing opioid prescribing for low back pain using multimodal mechanical stimulation vs. TENS: a randomized-controlled trial.Frontiers in pain research (Lausanne, Switzerland) · 2025Article
- Experiences of patients with endometriosis with a digital health application: a qualitative analysis.Archives of gynecology and obstetrics · 2024Article
- Clinical predictors of treatment response to gabapentin in women with unexplained chronic pelvic pain.Frontiers in pharmacology · 2024Article
- Positive, but not negative, treatment outcome expectancies mediate the relation between depressive symptoms and treatment-related pain reduction.Journal of behavioral medicine · 2023Article
- A Pilot Study of a Chronic Pain Self-Management Program Delivered by Community Health Workers to Underserved African American Older Adults.Pain medicine (Malden, Mass.) · 2022Article
- Psycho-Neuro-Endocrine-Immunological Basis of the Placebo Effect: Potential Applications beyond Pain Therapy.International journal of molecular sciences · 2022Review
- Engagement in Prescription Opioid Tapering Research: the EMPOWER Study and a Coproduction Model of Success.Journal of general internal medicine · 2022Article
- Non-invasive brain stimulation and pain neuroscience education in the cognitive-affective treatment of chronic low back pain: Evidence and future directions.Frontiers in pain research (Lausanne, Switzerland) · 2022Review
- Do individual psychological characteristics predict induction and generalization of nocebo and placebo effects on pain and itch?Frontiers in psychiatry · 2022Article
- Conditioning to Enhance the Effects of Repetitive Transcranial Magnetic Stimulation on Experimental Pain in Healthy Volunteers.Frontiers in psychiatry · 2022Article
- The Influence of Preoperative Mood and Treatment Expectations on Early Postsurgical Acute Pain After a Total Knee Replacement.Frontiers in psychiatry · 2022Article
- Brain circuits for pain and its treatment.Science translational medicine · 2021Review
- Article
- Effects of weekly pain monitoring on back pain outcomes: a non-randomised controlled study.Chiropractic & manual therapies · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Pain, a noxious psychosensory experience, motivates escape behavior to assure protection and survival. Psychological factors alter the experience and trajectory of pain, as well as behavior and treatment response. In the context of pain, the placebo effect (expectation for pain relief) releases endogenous opioids and facilitates analgesia from exogenously administered opioids. Nocebo hyperalgesia (expectation for persistent or worsening pain) opposes endogenous opioid analgesia and patient engagement in prescription opioid tapering. Reductions in nocebo hyperalgesia and pain catastrophizing may enhance descending modulation of pain, mediate adaptive structural brain changes and promote patient engagement in opioid tapering. Interventions that minimize nocebo and optimize placebo may adaptively shape the central nervous system toward pain relief and potentially opioid reduction. Here we provide a critical description of catastrophizing and its impact on pain, placebo and nocebo effects. We also consider the importance of minimizing nocebo and optimizing placebo effects during prescription opioid tapering, and offer a clinical toolkit of resources to accomplish these goals clinically.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.