ArticleClinical and molecular hepatology2018
Cardiac diastolic dysfunction predicts poor prognosis in patients with decompensated liver cirrhosis.
Article in Clinical and molecular hepatology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Liver cirrhosis and left ventricle diastolic dysfunction: Systematic review.World journal of gastroenterology · 2019Pooled it
- Cirrhotic cardiomyopathy: a systematic review and meta-analysis of prevalence across various diagnostic approaches.Annals of Saudi medicinePooled it
- Direct Bilirubin Is More Valuable than Total Bilirubin for Predicting Prognosis in Patients with Liver Cirrhosis.Gut and liver · 2021Trial
- Assessing the left atrial function via echocardiography to detect cirrhotic cardiomyopathy in patients with liver cirrhosis - a scoping review.Cardiovascular ultrasound · 2026Article
- Redox Imbalance in the Cardiohepatic Syndrome: The Emerging Role of Oxidative Stress in Cirrhosis-Associated Cardiac Dysfunction.Antioxidants (Basel, Switzerland) · 2026Review
- Echocardiographic Markers and Outcomes in End-Stage Liver Disease.Journal of clinical medicine · 2026Article
- Association of NT-proBNP and sST2 with Diastolic Dysfunction in Cirrhotic Patients and Its Therapeutic Implications.International journal of molecular sciences · 2025Article
- H2FPEF Scores Are Increased in Patients with NASH Cirrhosis and Are Associated with Post-liver Transplant Heart Failure.Digestive diseases and sciences · 2024Article
- Is Cirrhotic Cardiomyopathy Related to Cirrhosis Severity?Rambam Maimonides medical journal · 2023Article
- Factors Predicting Cardiac Dysfunction in Patients with Liver Cirrhosis.Middle East journal of digestive diseases · 2021Article
- Current Concepts of Cirrhotic Cardiomyopathy.Clinics in liver disease · 2021Review
- Interplay of cardiovascular mediators, oxidative stress and inflammation in liver disease and its complications.Nature reviews. Cardiology · 2021Review
- Diastolic Dysfunction Is a Predictor of Poor Survival in Patients with Decompensated Cirrhosis.International journal of hepatology · 2021Article
- Early echocardiographic signs of diastolic dysfunction predict acute kidney injury in cirrhotic patients.Journal of the Chinese Medical Association : JCMA · 2020Article
- Syndecan-1: A Review on Its Role in Heart Failure and Chronic Liver Disease Patients' Assessment.Cardiology research and practice · 2019Review
- Cirrhotic cardiomyopathy: An independent prognostic factor for cirrhotic patients.Clinical and molecular hepatology · 2018Article
- What's new in critical illness and injury science? Cardiac dysfunction in patients with cirrhosis and its correlation with Child - Turcott - Pugh (CTP) SCORE.International journal of critical illness and injury scienceArticle
- A case-cohort study of left ventricular diastolic dysfunction in patients with cirrhosis: the liver-heart axis.Annals of gastroenterologyArticle
Corrections and comments
- Commented on by
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimsLeft ventricular diastolic dysfunction (LVDD) is an early manifestation of cardiac dysfunction in patients with liver cirrhosis (LC). However, the effect of LVDD on survival has not been clarified, especially in decompensated LC.
methodsWe prospectively enrolled 70 patients with decompensated LC, including ascites or variceal bleeding, at Daejeon St. Mary's Hospital from April 2013 to April 2015. The cardiac function of these patients was evaluated using 2D echocardiography with tissue Doppler imaging. The diagnosis of LVDD was based on the American Society of Echocardiography guidelines. The primary endpoint was overall survival.
resultsForty-four patients (62.9%) had LVDD. During follow-up (22.3 months), 18 patients died (16 with LVDD and 2 without LVDD). The survival rate was significantly lower in patients with LVDD than in those without LVDD (31.1 months vs. 42.6 months, P=0.01). In a multivariate analysis, the Child-Pugh score and LVDD were independent predictors of survival. Moreover, patients with a ratio of early filling velocity to early diastolic mitral annular velocity (E/e') ≥ 10 (LVDD grade 2) had lower survival than patients with E/e' ratio < 10.
conclusionThe presence of LVDD is associated with poor survival in patients with decompensated LC. Therefore, it may be important to monitor and closely follow LVDD patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.