Evidence map›Paper›PMID 30145807›Full record

ReviewJournal of cellular and molecular medicine2018

The roles of TNFAIP2 in cancers and infectious diseases.

Lin Jia, Yundong Shi, Yi Wen, Wei Li, Jing Feng, Ceshi Chen

Open access · goldAbstract readReview
In one paragraph

Review in Journal of cellular and molecular medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 2 pooled it
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 2 syntheses or guidelines pooled it, 134 citations in OpenAlex.

  1. Pooled it
  2. Susceptibility ofTechnology in cancer research & treatment
    Pooled it
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. International journal of biological sciences · 2026
    Article
  13. Virulence · 2025
    Article
  14. Article
  15. Article
  16. Cells · 2025
    Review
  17. Article
  18. Article
  19. Article
  20. Article

9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Lin JiaDepartment of Biology, Yuxi Normal University, Yuxi, China.
Yundong ShiDepartment of Biology, Yuxi Normal University, Yuxi, China.
Yi WenKey Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.
Wei LiDepartment of Urology of the First People's Hospital of Yunnan Province, Kunming, China.
Jing FengDepartment of Laboratory Medicine & Central Laboratory, Southern Medical University Affiliated Fengxian Hospital, Shanghai, China.
Ceshi ChenKey Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.ORCID 0000-0001-6398-3516
Kunming Institute of Zoology · CNYuxi Normal University · CNKunming University of Science and Technology · CNXian Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

TNFα-induced protein 2 (TNFAIP2) is a primary response gene of TNFα. TNFAIP2 is highly expressed in immune cells and the urinary bladder. The expression of TNFAIP2 is regulated by multiple transcription factors and signalling pathways, including NF-κB, KLF5 and retinoic acid. Physiologically, TNFAIP2 appears to be a multiple functional mediator not only for inflammation, angiogenesis and tunneling nanotube (TNT) formation but also as a regulator of cell proliferation and migration. The expression of TNFAIP2 is frequently abnormal in human cancers and in infectious diseases. Due to its significant functions in cell proliferation, angiogenesis, migration and invasion, TNFAIP2 could be a potential diagnostic biomarker and therapeutic target for cancer.

Indexed as

Cell ProliferationCommunicable DiseasesCytokinesHumansNeoplasmsNeovascularization, PathologicNF-kappa BSignal TransductionTranscription Factor RelATumor Necrosis Factor-alphaCytokinesNF-kappa BRELA protein, humanTNFAIP2 protein, humanTranscription Factor RelATumor Necrosis Factor-alphaangiogenesisinflammationmigrationnanotube formationproliferationTNFAIP2

Identifiers

PMID30145807
PMCPMC6201362
OpenAlexW2888592268

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.