Evidence map›Paper›PMID 30145743›Full record

ArticleImmunologic research2018

The role of T regulatory cell-associated markers in monitoring tuberculosis treatment completion and failure.

Sonali Agrawal, Om Parkash, Alangudi Natarajan Palaniappan, Ashok K Bhatia, Santosh Kumar, Devendra S Chauhan, M Madhan Kumar

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Article in Immunologic research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Regulatory T Cells inFrontiers in immunology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sonali AgrawalDepartment of Immunology, National JALMA Institute for Leprosy and Other Mycobacterial Diseases, Agra, India.
Om ParkashDepartment of Immunology, National JALMA Institute for Leprosy and Other Mycobacterial Diseases, Agra, India.
Alangudi Natarajan PalaniappanDepartment of Clinic, National Institute for Research in Tuberculosis, Chennai, India.
Ashok K BhatiaDepartment of Biotechnology, GLA University, Mathura, India.
Santosh KumarDepartment of Tuberculosis & Chest Diseases, Sarojini Naidu Medical College, Agra, India.
Devendra S ChauhanDepartment of Microbiology and Molecular Biology, National JALMA Institute for Leprosy and Other Mycobacterial Diseases, Agra, India.
M Madhan KumarDepartment of Immunology, National JALMA Institute for Leprosy and Other Mycobacterial Diseases, Agra, India. madhanbiophile@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Monitoring tuberculosis (TB) treatment success is crucial for clinical decision-making. The only available tool in this regard is sputum microscopy, but it has demerits. Moreover, in case of smear negatives and extrapulmonary TB, an efficient tool is still sought for. Therefore, we evaluated T regulatory cell (Treg)-associated markers (CD25, CD39, and FoxP3) and cellular subsets in monitoring treatment success in treatment-completed groups. Expression profile of various markers and subsets were compared real time among treatment-naive pulmonary TB patients (TN-PTB), followed-up treatment-completed (TC-fu) cohort, and a not followed-up (TC-nfu) cohort. Peripheral blood mononuclear cells from various groups were incubated overnight and were stained with antibodies for specific markers and studied by flow cytometry. In both the treatment-completed groups, a decline in frequencies of CD25

Indexed as

AdolescentAdultAntigens, CDAntitubercular AgentsApyraseBiomarkersCell SeparationCohort StudiesFemaleFlow CytometryForkhead Transcription FactorsHumansInterleukin-2 Receptor alpha SubunitMaleMiddle AgedMycobacterium tuberculosisAntigens, CDAntitubercular AgentsApyraseBiomarkersCD39 antigenForkhead Transcription FactorsFOXP3 protein, humanInterleukin-2 Receptor alpha SubunitMarkerTB treatmentTreatment successTregTuberculosis

Identifiers

PMID30145743

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.