Evidence map›Paper›PMID 30145684›Full record

ArticleHistochemistry and cell biology2018

Valproate inhibits glucose-stimulated insulin secretion in beta cells.

Nikhil R Yedulla, Akshata R Naik, Keith M Kokotovich, Wenxi Yu, Miriam L Greenberg, Bhanu P Jena

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Histochemistry and cell biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. The clinical characterization of the adult patient with bipolar disorder aimed at personalization of management.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Nikhil R YedullaDepartment of Physiology, Wayne State University School of Medicine, 540 E. Canfield, 5245, 5215 Scott Hall, Detroit, MI, 48201, USA.
Akshata R NaikDepartment of Physiology, Wayne State University School of Medicine, 540 E. Canfield, 5245, 5215 Scott Hall, Detroit, MI, 48201, USA.
Keith M KokotovichDepartment of Physiology, Wayne State University School of Medicine, 540 E. Canfield, 5245, 5215 Scott Hall, Detroit, MI, 48201, USA.
Wenxi YuDepartment of Biological Sciences, Wayne State University, Detroit, MI, 48201, USA.
Miriam L GreenbergDepartment of Biological Sciences, Wayne State University, Detroit, MI, 48201, USA.
Bhanu P JenaDepartment of Physiology, Wayne State University School of Medicine, 540 E. Canfield, 5245, 5215 Scott Hall, Detroit, MI, 48201, USA. bjena@med.wayne.edu.ORCID http://orcid.org/0000-0002-6030-8766
Wayne State University · US

Funding

Novel Mechanisms of Regulation of Inositol BiosynthesisR01GM125082 · NIGMS · WAYNE STATE UNIVERSITY · PI GREENBERG, MIRIAM L · 2017 to 2020
$1.5M
National Institutes of Health R01 GM125082-05A1National Science Foundation CBET1066661NIGMS NIH HHS R01 GM125082
6 · The paper itself

Abstract

Valproate (VPA), an FDA approved anti-epileptic drug with a half-life of 12-18 h in humans, has been shown to perturb the vacuolar proton pump (vH

Indexed as

AnimalsGlucoseInsulinInsulin-Secreting CellsInsulin SecretionMiceTumor Cells, CulturedValproic AcidGlucoseInsulinValproic AcidInsulin secretionMin6 cellsSubunit CValproatevH+ ATPase

Identifiers

PMID30145684
PMCPMC6719693
OpenAlexW2888580437

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.