ArticleJournal of affective disorders2018
Differential engagement of cognitive control regions and subgenual cingulate based upon presence or absence of comorbid anxiety with depression.
Article in Journal of affective disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Psychotherapy and inhibitory control: Insights from fMRI research.Psychiatry and clinical neurosciences · 2026Pooled it
- Common and distinct patterns of brain activity alterations during inhibitory control in depression and psychostimulant users: a comparative meta-analysis of task-based fMRI studies.Psychological medicine · 2025Pooled it
- The relationship between emotional regulation and hemispheric lateralization in depression: a systematic review and a meta-analysis.Translational psychiatry · 2022Pooled it
- Investigating the feasibility and safety of transcranial infraslow gray noise stimulation as a potential treatment for generalized anxiety disorder.Scientific reports · 2025Trial
- Edge-centric connectome-genetic markers of bridging factor to comorbidity between depression and anxiety.Nature communications · 2024Article
- Relationship between brain structural network integrity and emotional symptoms in youth with perinatally-acquired HIV.Brain, behavior, and immunity · 2024Article
- Resting-State Brain Dynamics Unique to Anxiety in Major Depressive Disorder.Depression and anxiety · 2024Article
- Abnormal Degree Centrality in Zoster-Associated Pain with or Without Psychiatric Comorbidities: A Resting-State Functional MRI Study.Journal of pain research · 2024Article
- Altered functional connectivity in first-episode and recurrent depression: A resting-state functional magnetic resonance imaging study.Frontiers in neurology · 2022Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
backgroundMajor depressive disorder (MDD) and anxiety disorders are highly comorbid, sharing many similar symptoms, including impairments in cognitive control. Deficits in cognitive control could be a potential mechanism underlying impaired emotion regulation in mood disorders.
methodsParticipants were 44 individuals with no history of mental illness (healthy controls, HC), 31 individuals in the remitted state of MDD (rMDD), and 18 individuals who met lifetime DSM-IV-TR criteria for rMDD and an anxiety disorder in remission (Comorbid). Participants completed a Parametric Go/No-Go (PGNG) test during fMRI. Event-related analyses modeled activity for cognitive control successes (Hits for Targets, Rejections for Lures) and failures (Commissions on Lures) on the PGNG task.
resultsThe rMDD group showed significantly reduced activity within the cognitive control network (CCN) during Commission errors, including the middle frontal gyrus and inferior parietal lobule (IPL). The Comorbid group showed significantly reduced activity in several clusters within the CCN during correct Rejections, including the left IPL and right inferior frontal gyrus and greater subgenual cingulate. Notably, during correct Rejections, 60% of activation for the Comorbid group was within the Salience and Emotion Network (SEN), with 0% within the CCN. LIMITATIONS: The size of the Comorbid subgroup was modest, preventing subanalysis of the different AD subtypes.
conclusionsThere is evidence that CCN activity declines in rMDD and that there may be compensatory SEN activity in individuals with Comorbid rMDD and anxiety. Our findings support the identification of comorbid anxiety as a meaningful subtype of MDD that may obscure group differences between rMDD and HCs.
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