Evidence map›Paper›PMID 30145428›Full record

ArticleCell calcium2018

A screening campaign in sea urchin egg homogenate as a platform for discovering modulators of NAADP-dependent Ca

Gihan S Gunaratne, Malcolm E Johns, Hallie M Hintz, Timothy F Walseth, Jonathan S Marchant

Open access · greenAbstract read
In one paragraph

Article in Cell calcium, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. The protein interaction networks of mucolipins and two-pore channels.Biochimica et biophysica acta. Molecular cell research · 2019
    Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. NAADP-Mediated CaHandbook of experimental pharmacology · 2023
    Article
  7. Two-pore channels: going with the flows.Biochemical Society transactions · 2022
    Article
  8. Review
  9. NAADP-binding proteins find their identity.Trends in biochemical sciences · 2022
    Review
  10. Review
  11. Article
  12. Article
  13. The lysosomotrope GPN mobilises CaJournal of cell science · 2021
    Article
  14. Article
  15. Review
  16. Review
  17. NAADP Receptors.Cold Spring Harbor perspectives in biology · 2019
    Review
  18. Article
  19. Article
  20. Endolysosomal CaCancers · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Gihan S GunaratneDepartment of Pharmacology, University of Minnesota Medical School, MN 55455, USA.
Malcolm E JohnsDepartment of Pharmacology, University of Minnesota Medical School, MN 55455, USA.
Hallie M HintzDepartment of Pharmacology, University of Minnesota Medical School, MN 55455, USA.
Timothy F WalsethDepartment of Pharmacology, University of Minnesota Medical School, MN 55455, USA.
Jonathan S MarchantDepartment of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee WI 53226, USA. Electronic address: JMarchant@mcw.edu.
University of Minnesota Medical Center · USMedical College of Wisconsin · US

Funding

Functional architecture of IP3-evoked local Ca2+ signalsR01GM088790 · NIGMS · UNIVERSITY OF MINNESOTA · PI MARCHANT, JONATHAN S, SLAMA, JAMES T · 2009 to 2025
$4.7M
NIGMS NIH HHS R01 GM088790
6 · The paper itself

Abstract

The Ca

Indexed as

AnimalsCalciumCalcium SignalingCell LineDrug Evaluation, PreclinicalHumansLysosomesNADPOvumReproducibility of ResultsSea UrchinsCalciumNAADPNADPCa(2+)releaseDrug screeningEndosomesLysosomesNAADP

Identifiers

PMID30145428
PMCPMC6286156
OpenAlexW2885365001

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.