Evidence map›Paper›PMID 30145320›Full record

ArticleNeuropharmacology2018

Developmental role of adenosine kinase for the expression of sex-dependent neuropsychiatric behavior.

D M Osborne, U S Sandau, A T Jones, J W Vander Velden, A M Weingarten, N Etesami, Y Huo, H Y Shen, D Boison

Abstract read
In one paragraph

Article in Neuropharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Naringin Reverses Chronic Stress-Induced Cognitive Deficits and Enhances Hippocampal Neuroplasticity in Mice.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2026
    Article
  2. Article
  3. Mutation inFrontiers in cell and developmental biology · 2022
    Article
  4. Review
  5. Review
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

D M OsborneRobert Stone Dow Neurobiology Laboratories, Legacy Research Institute, Portland, OR, USA. Electronic address: dosborne@lhs.org.
U S SandauRobert Stone Dow Neurobiology Laboratories, Legacy Research Institute, Portland, OR, USA.
A T JonesRobert Stone Dow Neurobiology Laboratories, Legacy Research Institute, Portland, OR, USA.
J W Vander VeldenRobert Stone Dow Neurobiology Laboratories, Legacy Research Institute, Portland, OR, USA.
A M WeingartenRobert Stone Dow Neurobiology Laboratories, Legacy Research Institute, Portland, OR, USA.
N EtesamiRobert Stone Dow Neurobiology Laboratories, Legacy Research Institute, Portland, OR, USA.
Y HuoVascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA, USA.
H Y ShenRobert Stone Dow Neurobiology Laboratories, Legacy Research Institute, Portland, OR, USA.
D BoisonRobert Stone Dow Neurobiology Laboratories, Legacy Research Institute, Portland, OR, USA.
Legacy Health · USAugusta University · US

Funding

Adenosine and schizophrenia: mechanisms and therapiesR01MH083973 · NIMH · LEGACY EMANUEL HOSPITAL AND HEALTH CENTER · PI BOISON, DETLEV · 2009 to 2015
$2.5M
The role of adenosine kinase in atherosclerosisR01HL095556 · NHLBI · UNIVERSITY OF MINNESOTA · PI HUO, YUQING · 2011 to 2015
$1.5M
NHLBI NIH HHS R01 HL095556NIH HHS 5R01MH083973-07NIMH NIH HHS R01 MH083973
6 · The paper itself

Abstract

Deficits in social memory, cognition, and aberrant responses to stimulants are common among persons affected by schizophrenia and other conditions with a presumed developmental etiology. We previously found that expression changes in the adenosine metabolizing enzyme adenosine kinase (ADK) in the adult brain are associated with deficits in various cognitive domains. To distinguish between developmental and adult functions of ADK, we used two transgenic mouse lines with widespread disruption of ADK expression in the adult brain, but differences in the onset of ADK deletion. Specifically, we compared Nestin-Cre

Indexed as

Sex CharacteristicsAdenosine KinaseAge FactorsAmphetamineAnimalsCentral Nervous System SensitizationFemaleHSP40 Heat-Shock ProteinsLearningMaleMemoryMiceMice, TransgenicNestinAdenosine KinaseAmphetamineHSP40 Heat-Shock ProteinsNes protein, mouseNestinAdenosine kinaseAttention deficit hyperactivity disorderAutismBrain developmentSchizophreniaSex differences

Identifiers

PMID30145320
PMCPMC6867705
OpenAlexW2888101500

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.