ArticleDevelopmental biology2018
Fate-restricted retinal progenitor cells adopt a molecular profile and spatial position distinct from multipotent progenitor cells.
Article in Developmental biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 44 citations in OpenAlex.
- Article
- Evolutionary conservation of VSX2 super-enhancer modules in retinal development.Development (Cambridge, England) · 2024Article
- Single-cell RNA sequencing unravels the transcriptional network underlying zebrafish retina regeneration.eLife · 2023Article
- Molecular mechanisms controlling vertebrate retinal patterning, neurogenesis, and cell fate specification.Trends in genetics : TIG · 2023Review
- Disease-causing mutations in genes encoding transcription factors critical for photoreceptor development.Frontiers in molecular neuroscience · 2023Review
- Deletion of histone demethylaseFrontiers in cellular neuroscience · 2023Article
- Cell Fate of Retinal Progenitor Cells: In Ovo UbC-StarTrack Analysis.International journal of molecular sciences · 2022Article
- Identification of a modular super-enhancer in murine retinal development.Nature communications · 2022Article
- Early cis-regulatory events in the formation of retinal horizontal cells.Developmental biology · 2021Article
- Notch signaling represses cone photoreceptor formation through the regulation of retinal progenitor cell states.Scientific reports · 2021Article
- A defined subset of clonal retinal stem cell spheres is biased to RPE differentiation.iScience · 2021Article
- Cis-regulatory dissection of cone development reveals a broad role for Otx2 and Oc transcription factors.Development (Cambridge, England) · 2021Article
- OTX2 represses sister cell fate choices in the developing retina to promote photoreceptor specification.eLife · 2020Article
- Cis-regulatory analysis of Onecut1 expression in fate-restricted retinal progenitor cells.Neural development · 2020Article
- Wiring the Binocular Visual Pathways.International journal of molecular sciences · 2019Review
- Identification of Genes With Enriched Expression in Early Developing Mouse Cone Photoreceptors.Investigative ophthalmology & visual science · 2019Article
- Lineage tracing analysis of cone photoreceptor associated cis-regulatory elements in the developing chicken retina.Scientific reports · 2019Article
- Quantitative analysis of the ThrbCRM1-centered gene regulatory network.Biology open · 2019Article
- Identification and characterization of early photoreceptor cis-regulatory elements and their relation to Onecut1.Neural development · 2018Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
During development, multipotent retinal progenitor cells generate a large number of unique cell types. Recent evidence suggests that there are fate-restricted progenitor cell states in addition to multipotent ones. Here we report a transcriptomic analysis of fate- restricted progenitor cells biased to produce cone photoreceptors and horizontal cells, marked by the THRB cis-regulatory element ThrbCRM1. Comparison to a control population enriched in multipotent progenitor cells identified several genes considered to be pan-progenitor, such as VSX2, LHX2, and PAX6, as downregulated in these fate- restricted retinal progenitor cells. This differential regulation occurs in chick and in a different restricted progenitor population in mouse suggesting that this is a conserved feature of progenitor dynamics during retinal development. S-phase labeling also revealed that nuclear positions of restricted progenitor populations occupy distinct spatial niches within the developing chick retina. Using a conserved regulatory element proximal to the VSX2 gene, a potential negative feedback mechanism from specific transcription factors enriched in cone/horizontal cell progenitor cells was identified. This study identifies conserved molecular and cellular changes that occur during the generation of fate restricted retinal progenitor cells from multipotent retinal progenitor cells.
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