Evidence map›Paper›PMID 30145015›Full record

ArticleProgress in biophysics and molecular biology2019

Tropomyosin dynamics during cardiac muscle contraction as governed by a multi-well energy landscape.

Yasser Aboelkassem, Natalia Trayanova

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Progress in biophysics and molecular biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Yasser AboelkassemInstitute for Computational Medicine, Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA. Electronic address: yaboelkassem@ucsd.edu.
Natalia TrayanovaInstitute for Computational Medicine, Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Johns Hopkins University · US

Funding

Virtual Electrophysiology LaboratoryDP1HL123271 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI TRAYANOVA, NATALIA A. · 2013 to 2017
$4.0M
Resynchronizing the Failing Heart: Insights from a Multiscale Cardiac ModelR01HL103428 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI TRAYANOVA, NATALIA A. · 2011 to 2014
$2.3M
NHLBI NIH HHS DP1 HL123271NHLBI NIH HHS R01 HL103428
6 · The paper itself

Abstract

The dynamic oscillations of tropomyosin molecules in the azimuthal direction over the surface of the actin filament during thin filament activation are studied here from an energy landscape perspective. A mathematical model based on principles from nonlinear dynamics and chaos theory is derived to describe these dynamical motions. In particular, an energy potential with three wells is proposed to govern the tropomyosin oscillations between the observed regulatory positions observed during muscle contraction, namely the blocked "B", closed "C" and open "M" states. Based on the variations in both the frequency and amplitude of the environmental (surrounding the thin filament system) driving tractions, such as the electrostatic, hydrophobic, and Ca

Indexed as

Models, BiologicalMyocardial ContractionCalciumMovementNonlinear DynamicsThermodynamicsTropomyosinCalciumTropomyosinCardiac muscle contractionChaos theoryMyofilament modelingTropomyosin dynamics

Identifiers

PMID30145015
PMCPMC6386637
OpenAlexW2888607237

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.