Evidence map›Paper›PMID 30144829›Full record

ArticleEuropean journal of medical research2018

Vasomotion of mice mesenteric arteries during low oxygen levels.

J Westhoff, K Weismüller, C Koch, V Mann, M A Weigand, M Henrich

Open access · goldAbstract read
In one paragraph

Article in European journal of medical research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Hif1α-dependent mitochondrial acute ONature communications · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

J WesthoffDepartment of Anesthesiology and Intensive Care Medicine, Justus-Liebig University Giessen, Rudolph-Buchheimstr. 7, 35392, Giessen, Germany.
K WeismüllerDepartment of Anesthesiology and Intensive Care Medicine, Justus-Liebig University Giessen, Rudolph-Buchheimstr. 7, 35392, Giessen, Germany.
C KochDepartment of Anesthesiology and Intensive Care Medicine, Justus-Liebig University Giessen, Rudolph-Buchheimstr. 7, 35392, Giessen, Germany.
V MannDepartment of Anesthesiology and Intensive Care Medicine, Justus-Liebig University Giessen, Rudolph-Buchheimstr. 7, 35392, Giessen, Germany.
M A WeigandDepartment of Anesthesiology and Intensive Care Medicine, Heidelberg University Hospital, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany.
M HenrichDepartment of Anesthesiology and Intensive Care Medicine, Justus-Liebig University Giessen, Rudolph-Buchheimstr. 7, 35392, Giessen, Germany. michael.henrich@vincentius-ka.de.
University of Giessen · DESt. Vincentius-Kliniken · DEUniversity Hospital Heidelberg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIschemia of intestinal organs is a main cause of complications in surgical intensive care patients. Changes in the tonus of arteries contributing to vascular resistance play an important role in the determination of blood flow and thus oxygen supply of various abdominal organs. It is generally acknowledged that hypoxia itself is able to alter arterial tonus and thus blood flow.

methodsThe present study compared the effects of various degrees of hypoxia on second-order mesenteric arteries from male C57BL/6J mice. After vessel isolation and preparation, we assessed vessel diameter using an arteriograph perfusion chamber. Investigating mechanisms promoting hypoxia-induced vasodilatation, we performed experiments in Ca

resultsMild hypoxia 14.4% O

conclusionsThe present study demonstrated that hypoxic vasodilatation in mice mesenteric arteries is mediated by a NO-independent mechanism. In this experimental setting, we found evidence for Ca

Indexed as

HypoxiaVascular ResistanceAnimalsCalciumMaleMesenteric ArteriesMiceMice, Inbred C57BLMice, KnockoutNerve Tissue ProteinsNitric Oxide Synthase Type IIIOxygenPotassium Channels, Tandem Pore DomainVasodilationCalciumNerve Tissue ProteinsNitric Oxide Synthase Type IIINos3 protein, mouseOxygenPotassium Channels, Tandem Pore Domainpotassium channel subfamily K member 3HypoxiaMesenteric arteryMiceVasomotion

Identifiers

PMID30144829
PMCPMC6109325
OpenAlexW2888265619

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.