ArticleJournal of affective disorders2018
Lifetime affective problems and later-life cognitive state: Over 50 years of follow-up in a British birth cohort study.
Article in Journal of affective disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Contribution of accumulative affective problems across the life course towards the association of childhood socioeconomic position with later-life cognitive ageing.European journal of ageing · 2026Article
- Longitudinal associations of psychological distress with subsequent cognitive decline and dementia: a multi-cohort study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Higher purpose in life and education were associated with better cognition among older adults.Arquivos de neuro-psiquiatria · 2024Article
- Updating the study protocol: Insight 46 - a longitudinal neuroscience sub-study of the MRC National Survey of Health and Development - phases 2 and 3.BMC neurology · 2024Article
- Article
- Timing of physical activity across adulthood on later-life cognition: 30 years follow-up in the 1946 British birth cohort.Journal of neurology, neurosurgery, and psychiatry · 2023Article
- The Power of Birth Cohorts to Study Risk Factors for Cognitive Impairment.Current neurology and neuroscience reports · 2022Review
- Salivary cortisol in longitudinal associations between affective symptoms and midlife cognitive function: A British birth cohort study.Journal of psychiatric research · 2022Article
- Metabolic correlates of late midlife cognitive outcomes: findings from the 1946 British Birth Cohort.Brain communications · 2022Article
- Investigating the Relationship Between IGF-I, IGF-II, and IGFBP-3 Concentrations and Later-Life Cognition and Brain Volume.The Journal of clinical endocrinology and metabolism · 2021Article
- Depression, dementia and immune dysregulation.Brain : a journal of neurology · 2021Article
- Longitudinal associations between diurnal cortisol variation and later-life cognitive impairment.Neurology · 2020Article
- Longitudinal associations of affective symptoms with mid-life cognitive function: evidence from a British birth cohort.The British journal of psychiatry : the journal of mental science · 2019Article
- Midlife Psychological Well-Being and its Impact on Cognitive Functioning Later in Life: An Observational Study Using a Female British Birth Cohort.Journal of Alzheimer's disease : JAD · 2019Observational
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundAffective problems increase the risk of dementia and cognitive impairment, yet the life course dimension of this association is not clearly understood. We aimed to investigate how affective problems across the life course relate to later-life cognitive state.
methodsData from 1269 participants from the Medical Research Council National Survey of Health and Development (NSHD, the British 1946 birth cohort) were used. Prospectively-assessed measures of affective symptoms spanning ages 13-69 and categorised into case-level thresholds. Outcomes consisted of a comprehensive measure of cognitive state (Addenbrooke's Cognitive Examination (ACE-III)), verbal memory, and letter search speed and accuracy at age 69.
resultsComplementary life course models demonstrated that having 2 or more case-level problems across the life course was most strongly associated with poorer cognitive outcomes, before and after adjusting for sex, childhood cognition, childhood and midlife occupational position and education. LIMITATIONS: A disproportionate loss to follow-up of those who had lower childhood cognitive scores may have led to underestimation of the strength of associations. DISCUSSION: Using a population-based prospective study we provide evidence that recurrent lifetime affective problems predicts poorer later-life cognitive state, and this risk can be already manifest in early old age (age 69). Our findings raise the possibility that effective management to minimise affective problems reoccurring across the life course may reduce the associated risk of cognitive impairment and decline.
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