ArticleJournal of magnetic resonance (San Diego, Calif. : 1997)2018
Determination of binding affinities using hyperpolarized NMR with simultaneous 4-channel detection.
Article in Journal of magnetic resonance (San Diego, Calif. : 1997), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Accelerated Screening of Protein-Ligand Interactions via ParallelAnalytical chemistry · 2024Article
- Parallel detection of chemical reactions in a microfluidic platform using hyperpolarized nuclear magnetic resonance.Lab on a chip · 2023Article
- Selective Isotope Labeling and LC-Photo-CIDNP Enable NMR Spectroscopy at Low-Nanomolar Concentration.Journal of the American Chemical Society · 2022Article
- Detection of Protein-Ligand Interactions byThe journal of physical chemistry letters · 2022Article
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Authors and funding
3 authors.
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Abstract
Dissolution dynamic nuclear polarization (D-DNP) is a powerful technique to improve NMR sensitivity by a factor of thousands. Combining D-DNP with NMR-based screening enables to mitigate solubility or availability problems of ligands and target proteins in drug discovery as it can lower the concentration requirements into the sub-micromolar range. One of the challenges that D-DNP assisted NMR screening methods face for broad application, however, is a reduced throughput due to additional procedures and time required to create hyperpolarization. These requirements result in a delay of several tens of minutes in-between each NMR measurement. To solve this problem, we have developed a simultaneous 4-channel detection method for hyperpolarized
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